Liu, B., Shen, M., Xiong, J., et al. (2015) Synergistic Effects of Betel Quid Chewing, Tobacco Use (in the Form of Cigarette Smoking), and Alcohol Consumption on the Risk of Malignant Transformation of Oral Submucous Fibrosis (OSF): A Case-Control Study in Hunan Province, China. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 120, 337-345.
https://doi.org/10.1016/j.oooo.2015.04.013

has been cited by the following article:

• TITLE: Second Primary Oral Squamous Cell Carcinoma after Radiotherapy: A Retrospective Study, over 5 Years, about 27 Cases

  AUTHORS: Amira Saoudi, Oumaima Siyouri, Samia Mhirech, Hajar Medyouni, Jihane Chouef, Soussy Kawtar, Lamiae Amaadour, Karima Oualla, Zineb Benbrahim, Wissal Hassani, Fatimazahra Farhane, Zenab Alami, Samia Arifi, Nawfel Mellas, Touria Bouhafa

  KEYWORDS: Second Primary, Malignancy, Squamous Cell Carcinoma, Oral Cavity, Radiation

  JOURNAL NAME: Open Access Library Journal, Vol.11 No.5, May 10, 2024

  ABSTRACT: Background: The purpose of the present study was to investigate the clinicopathological characteristics and prognostic factors of second primary oral squamous cell carcinoma after radiotherapy for head and neck cancer. Methods: The clinicopathological characteristics of 27-second primary oral squamous cell carcinoma patients with a history of radiotherapy for head and neck cancer were retrospectively analyzed by Kaplan-Meier survival analysis and Cox proportional hazards model, including gender, age, alcohol consumption, smoking, clinical stage, margin status, regional lymph node status, tumor differentiation and treatment mode. Results: The second primary oral squamous cell carcinoma mostly occurred on the tongue (11/27), buccal (9/27) and gingiva (7/27), and the 3- and 5-year overall survival (OS) was 60.3% and 39.4%, respectively. Margin status and extranodal extension were significantly associated with OS, while only margin status was found to be an independent prognostic factor of OS in the Cox proportional hazards model (P = 0.003, HR = 3.976, 95% CI: 1.596 - 9.904). Conclusion: Oral squamous cell carcinoma patients who underwent radiotherapy for head and neck cancer show poor survival outcomes. Margin status is an independent prognostic factor of second primary oral squamous cell carcinoma.