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has been cited by the following article:

• TITLE: Spirulina platensis Alleviates the Liver, Brain and Heart Oxidative Stress in Type 1 Diabetic Rats

  AUTHORS: Francisca Adilfa de Oliveira Garcia, Violet G. Yuen, Helioswilton Sales de Campos, Eveline Turatti, Glauce Socorro de Barros Viana, Carlo José Freire Oliveira, John H. McNeill

  KEYWORDS: Spirulina platensis, Lipid Profile, Cardiac Function, Oxidative Stress, Diabetes

  JOURNAL NAME: Food and Nutrition Sciences, Vol.9 No.6, June 28, 2018

  ABSTRACT: Spirulina platensis (SPI) is a microalga with a high content of functional compounds, such as phenolics, phycocyanins and polysaccharides that has been shown to have antioxidant, anti-inflammatory, hypoglycemic, neuro-protective and immunomodulatory effects. The objectives of the present work were to study the possible effects of SPI treatment on the glycemic-lipid profile, oxidative stress, lipid peroxidation and cardiac performance in diabetic rats. Diabetes was induced by streptozotocin (STZ) in male Wistar rats. In diabetic animals SPI, at a dose of 50 mg/kg/day, reduced lipid peroxidation, nitrite levels and lipids in plasma and tissues. SPI exhibited an effective improvement on +dP/dT and −dP/dT in non-diabetic rats. This study showed that SPI significantly suppressed nitrite generation and lipoperoxidation in the hearts of diabetic animals, as well as an improvement in the cardiac function in control SPI-treated rats which is consistent with several studies that demonstrated the protective effect of antioxidants on oxidative stress-mediated injury caused by reactive oxygen species (ROS) produced in diabetic myocardial tissues.