Legro, R.S., Barnhar, T.H.X., Schlaff, W.D., Carr, B.R., Diamond, M.P., Carson, S.A., Steinkampf, M.P., Coutifaris, C., Mcgovern, P.G., Cataldo, N.A., Gosman, G.G., Nestler, J.E., Giudice, L.C., Leppert, P.C. and Myers, E.R., Cooperative Multicenter Reproductive Medicine Network (2007) Clomiphene, Metformin, or Both for Infertility in the Polycystic Ovary Syndrome. The New England Journal of Medicine, 356, 551-566. http://dx.doi.org/10.1056/NEJMoa063971

has been cited by the following article:

• TITLE: Polycystic Ovary Syndrome (PCOS) and Fertility

  AUTHORS: Guilherme Barbosa, Larissa Bianca Paiva Cunha de Sá, Denise Rosso Tenório Wanderley Rocha, Alberto Krayyem Arbex

  KEYWORDS: Polycystic Ovary Syndrome, Infertility, Anovulation, Hyperandrogenism, Insulin Resistance

  JOURNAL NAME: Open Journal of Endocrine and Metabolic Diseases, Vol.6 No.1, January 21, 2016

  ABSTRACT: The polycystic ovary syndrome (PCOS) is defined as a combination of hyperandrogenism (hirsutism and acne) and anovulation (oligomenorrhea, infertility, and dysfunctional uterine bleeding), with or without the presence of polycystic ovaries on ultrasound. It represents the main endocrine disorder in the reproductive age, affecting 6% - 15% of women in menacme. It is the most common cause of infertility due to anovulation, and the main source of female infertility. When in the presence of a menstrual disorder, the diagnosis of PCOS is reached in 30% - 40% of patients with primary or secondary amenorrhoea and in 80% of patients with oligomenorrhea. PCOS should be diagnosed and treated early in adolescence due to reproductive, metabolic and oncological complications which may be associated with it. Treatment options include drugs, diet and lifestyle improvement.