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has been cited by the following article:

• TITLE: Rare Case of a Patient Presenting with Parathyroid Hormone-Related Peptide Mediated Hypercalcemia and IgG Heavy Chain Disease: Case Report and Review of Literature

  AUTHORS: Damien Hansra, Diaz Liege, Victoria Sujoy, Ikpatt Offiong, Chris Wunsch, James E. Hoffman

  KEYWORDS: Hypercalcemia, Parathyroid Hormone-Related Peptide (PTHrP), Franklin Disease, Heavy Chain Myeloma

  JOURNAL NAME: Open Journal of Blood Diseases, Vol.5 No.3, September 16, 2015

  ABSTRACT: IgG Heavy Chain Disease (γHCD) is a rare plasma cell disorder. Hypercalcemia related to plasma cell dyscrasias is related to non-PTHrP related mechanisms. Here we describe the first case of a patient with γHCD and PTHrP related hypercalcemia. Methods: Patient case derived from chart review from 2011 to 2015. Literature review performed searching PubMed 1968-current. Results: The patient was diagnosed with hypercalcemia with elevated PTHrP and exclusion of other etiologies of hypercalcemia. She was diagnosed with (γHCD) by M-spike 0.64 g/dL, IFE showing a broad band of IgG heavy chain, without associated light chains and severe depression of the non-mono-clonal IgG. Serum immunoglobulins demonstrated elevated IgG (2110 mg/dL), normal IgA (46 mg/dL) and decreased IgM (