Prof. Karel Marcel Allegaert

Katholieke Universiteit Leuven, Belgium

Email: karel.allegaert@uz.kuleuven.ac.be

Qualifications

Publications (Selected)

1. Bertagnolio, S., Dobreva, Z., Centner, C. M., Olaru, I. D., Donà, D., Burzo, S., ... & Kotwani, A. (2024). WHO global research priorities for antimicrobial resistance in human health. The Lancet Microbe.
2. Keij, F. M., Kornelisse, R. F., Hartwig, N. G., Van der Sluijs-Bens, J., van Beek, R. H., van Driel, A., ... & Tramper-Stranders, G. A. (2022). Efficacy and safety of switching from intravenous to oral antibiotics (amoxicillin–clavulanic acid) versus a full course of intravenous antibiotics in neonates with probable bacterial infection (RAIN): a multicentre, randomised, open-label, non-inferiority trial. The Lancet Child & Adolescent Health, 6(11), 799-809.
3. Allegaert, K., & van den Anker, J. (2021). Dose‐Related Adverse Drug Events in Neonates: Recognition and Assessment. The Journal of Clinical Pharmacology, 61, S152-S160.
4. Ceulemans, M., Foulon, V., Panchaud, A., Winterfeld, U., Pomar, L., Lambelet, V., ... & Nordeng, H. (2021). Vaccine willingness and impact of the COVID-19 pandemic on women’s perinatal experiences and practices—A multinational, cross-sectional study covering the first wave of the pandemic. International journal of environmental research and public health, 18(7), 3367.
5. Vinarov, Z., Abdallah, M., Agundez, J. A., Allegaert, K., Basit, A. W., Braeckmans, M., ... & Augustijns, P. (2021). Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: An UNGAP review. European Journal of Pharmaceutical Sciences, 162, 105812.
6. Schrier, L., Hadjipanayis, A., Stiris, T., Ross-Russell, R. I., Valiulis, A., Turner, M. A., ... & van Den Anker, J. (2020). Off-label use of medicines in neonates, infants, children, and adolescents: a joint policy statement by the European Academy of Paediatrics and the European society for Developmental Perinatal and Pediatric Pharmacology. European journal of pediatrics, 179, 839-847.
7. Ceulemans, M., Verbakel, J. Y., Van Calsteren, K., Eerdekens, A., Allegaert, K., & Foulon, V. (2020). SARS-CoV-2 infections and impact of the COVID-19 pandemic in pregnancy and breastfeeding: Results from an observational study in primary care in Belgium. International journal of environmental research and public health, 17(18), 6766.
8. Allegaert, K., Smits, A., Van Donge, T., Van den Anker, J., Sarafidis, K., Levtchenko, E., & Mekahli, D. (2020). Renal precision medicine in neonates and acute kidney injury: how to convert a cloud of creatinine observations to support clinical decisions. Frontiers in pediatrics, 8, 366.
9. Allegaert, K., & van den Anker, J. (2019). Ontogeny of phase I metabolism of drugs. The Journal of Clinical Pharmacology, 59, S33-S41.
10. Allegaert, K., Mian, P., Lapillonne, A., & van den Anker, J. N. (2019). Maternal paracetamol intake and fetal ductus arteriosus constriction or closure: a case series analysis. British journal of clinical pharmacology, 85(1), 245-251.
11. Colin, P. J., Allegaert, K., Thomson, A. H., Touw, D. J., Dolton, M., de Hoog, M., ... & Eleveld, D. J. (2019). Vancomycin pharmacokinetics throughout life: results from a pooled population analysis and evaluation of current dosing recommendations. Clinical pharmacokinetics, 58, 767-780.
12. Van den Anker, J., Reed, M. D., Allegaert, K., & Kearns, G. L. (2018). Developmental changes in pharmacokinetics and pharmacodynamics. The Journal of Clinical Pharmacology, 58, S10-S25.
13. Luyckx, V. A., Perico, N., Somaschini, M., Manfellotto, D., Valensise, H., Cetin, I., ... & Steegers, E. A. (2017). A developmental approach to the prevention of hypertension and kidney disease: a report from the Low Birth Weight and Nephron Number Working Group. The Lancet, 390(10092), 424-428.
14. Allegaert K (2011). Mechanism based medicine in infancy: complex interplay between developmental pharmacology and pharmacogenetics.International Journal of Clinical Pharmacy 33(3):473-474.
15. Allegaert K, Palmer G, Anderson B (2011). The pharmacokinetics of intravenous paracetamol in neonates: size matters most.Archives of Disease in Childhood 96(6):575-580.
16. Thewissen L, Allegaert K (2011). analgosedation in neonates: do we still need additional tools after 30 years of clinical research ?Archives of Disease in Childhood. Education and Practice Edition 96(3):112-118.
17. de Cock R, Piana C, Krekels E, Danhof M, Allegaert K, Knibbe C (2011). The role of population PK–PD modelling in paediatric clinical research.European Journal of Clinical Pharmacology 67(S1):S5-S16.
18. Kulo A, Allegaert K, de Hoon J, Verbesselt R (2011). Determination of Propylene Glycol in Low Volume Plasma and Urine Samples of Neonates by LC with Photodiode Array Detection.Chromatographia 73(5-6):463-470.
19. Allegaert K, Rochette A, Veyckemans F (2011). Developmental pharmacology of tramadol during infancy: ontogeny, pharmacogenetics and elimination clearance.Paediatric Anaesthesia 21(3):266-273.
20. Hopchet L, Kulo A, Rayyan M, Verbesselt R, Vanhole C, de Hoon J, Allegaert K. (2011). Does intravenous paracetamol administration affect body temperature in neonates ?Archives of Disease in Childhood 96(3):301-304.
21. Allegaert K, Peeters M, Knibbe CA (2011). Propofol in (pre)term neonates: consider the extensive interindividual variability in clearance within the neonatal population.Paediatric Anaesthesia 21(2):174-175.
22. Doné E, Allegaert K, Lewi P, Jani J, Gucciardo L, Van Mieghem T, Gratacos E, Devlieger R, Van Schoubroeck D, Deprest J (2011). Maternal hyperoxygenation test in fetuses undergoing FETO for severe isolated congenital diaphragmatic hernia.Ultrasound in obstetrics & gynecology: the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 37(3):264-271.
23. Allegaert K, Vanhaesebrouck S, Kulo A, Cosaert K, Verbesselt R, Debeer A, de Hoon J (2010). Prospective assessment of short-term propylene glycol tolerance in neonates.Archives of Disease in Childhood 95(12):1054-1058.
24. Wildschut E, Ashman M, Allegaert K, Mathot R, Tibboel D (2010). Determinants of drug absorption in different ECMO circuits.Intensive Care Medicine 36(12):2109-2116.
25. Allegaert K, Smet M, Debeer A, Breysem L (2010). Bladder catheter-induced obstructive bilateral hydroureteronephrosis in a newborn.Acta Paediatrica 99(11), 1747-1749.
26. Allegaert K, Naulaers G. (2010). Gabapentin as part of multimodal analgesia in a newborn with epidermolysis bullosa.Paediatric Anaesthesia20 (10):972-973.
27. Breysem L, Debeer A, Claus F, Proesmans M, De Keyzer F, Lewi P, Allegaert K, Smet M, Deprest J (2010). Cross-sectional study of tracheomegaly in children after fetal tracheal occlusion for severe congenital diaphragmatic hernia.Radiology 257(1):226-232.
28. Mijovic B, Silva M, Van den Bergh B, Allegaert K, Aerts J, Berckmans D, Van Huffel S (2010). Assessment of pain expression in infant cry signals using Empirical Mode Decomposition.Methods of Information in Medicine 49(5):448-452.
29. Allegaert K, Naulaers G (2010). Haemodynamics of intravenous paracetamol in neonates.European Journal of Clinical Pharmacology 66(9):855-858.
30. Anderson B, Allegaert K (2010). The pharmacology of anaesthetics in the neonate.Best Practice & Research. Clinical Anaesthesiology 24(4):419-431.
31. Breckpot J, Thienpont B, Peeters H, de Ravel T, Singer A, Rayyan M, Allegaert K, Vanhole C, Eyskens B, Vermeesch J, Gewillig M, Devriendt K (2010). Array Comparative Genomic Hybridization as a Diagnostic Tool for Syndromic Heart Defects.Journal of Pediatrics 156(5):810-817.
32. Peeters M, Allegaert K, Blussé van Oud-Alblas H, Cella M, Tibboel D, Danhof M, Knibbe CA (2010). Prediction of propofol clearance in children form an allometric model developed in rats, children and adults versus a 0.75 fixed-exponent allometric model.Clinical Pharmacokinetics 49(4):269-275.
33. Allegaert K, Casteels I, Tibboel D (2010). Pain management during eye examinations for retinopathy of prematurity: what about procedural adaptations to blunt the pain response ?Acta Paediatrica 99(4):488-489.

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