In the current global epidemic for chronic diseases such as non
alcoholic fatty liver disease (NAFLD), obesity, diabetes and neurodegenerative
diseases such as Alzheimer’s disease and Parkinson’s disease have become of
major concern to the developed and developing world. Appetite regulation is
involved in the aging process with the repression of anti-aging genes connected
to insulin resistance and neurodegenerative diseases. Interests in the
gene-environment interactions indicate that the anti-aging genes are connected
to the metabolism of bacterial lipopolysaccharides (LPS), drugs and
xenobiotics. In the developing world relevance to gram negative bacteria and
increased plasma bacterial lipopolysaccharides (LPS) outer membrane endotoxins
bindto cell membranes and interfere with cholesterol and amyloid beta (Aβ) interactionswith repression of
anti-aging genes to mediate accelerated neuron death. Biotherapeutics and
nutritional biotherapy have become important to reverse these global chronic
diseases. Biotherapeutics that involve Indian spice therapy require
reassessment with relevance to insulin therapy, immunotherapy, antimicrobial
therapy and drug therapeutics. Combined insulin and Indian spice therapy
interferes with human insulin biological activity relevant to the prevention of
uncontrolled intracellular glucose levels and mitochondrial apoptosis.
Magnesium therapy reverses cell senescence associated with various chronic diseases
such as cardiovascular disease, diabetes and Alzheimer’s disease. Factors such
as stress, core body temperature and food quality influence biotherapeutics
with prevention of NAFLD, diabetes and neurodegenerative diseases.