TITLE:
The effect of administrating hyoscine bromide on pregnancy rate before embryo transfer in ART cycles
AUTHORS:
Mahvash Zargar, Shiva Kajbaf, Masoud Hemadi
KEYWORDS:
Assisted Reproductive Technology (ART); Hyoscine; Pregnancy; Embryo Transfer
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.3 No.7,
September
27,
2013
ABSTRACT:
Assisted
reproductive technology methods i.e.,
IVF and ICSI were extensively used for treatment of infertility. Although, these
methods have many advantages but ART pregnancy rate remains low (30% - 35%). It seems
that uterine peristalsis occurred after rhCG administration in turn resulting to
impair implantation of the transferred embryos. Therefore this study was conducted
to possess of whether hyoscine bromide can effectively alleviate uterine contraction
and then have any effect on the reproductive outcome. Healthy women who underwent
IVF or ICSI cycles (n = 142) were randomly assigned to one of two groups at the
start of the cycle. Group control (n = 71) without applied hyoscine and group experiment
(n = 71) applied hyoscine (25 mg). Controlled ovarian hyperstimulation was induced
with follicle stimulating hormone (FSH). Sperm preparation and ovarian puncture
for in vitro maturation and fertilization
(IVF) of oocyte were carried out for 42 hours after rhCG injection. Two weeks after
rhCG injection, bhCG pregnancy test to determine pregnancy outcome in both groups
was done and the outcome results, along with other information were recorded separately. The pregnancy rate in experimental
group was significantly higher than that of control group. when all of the cycles
with or without giving 25 mg of hyosine were stratified by the mean total follicles
(more/less than 2 follicles) and embryos (more/less than25 kg/m2), the Patients’ age, the quality grade
of embryos and infertility duration (more/less than 5 years), the reproductive outcome,
in overall, in the subjects with more than 10 oocytes, 5 embryos, more than quality
A and B grades of embryos, less than 35 years age and also less than 5 years infertility
duration was more pronounced than the other patients. But the other parameter was
not affected by the reproductive outcome. Clinical or statistical improvement of
the reproductive outcome could be demonstrated in the hyosine treated group especially
with increasing the mean total follicles, embryo, quality of embryo in women with
low age and infertility duration. However, further well-designed studies are essential
to offer a final conclusion.