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has been cited by the following article:

• TITLE: Design, Synthesis and Pharmacological Evaluation of New Nonsteroidal Anti-Inflammatory Derived from 3-Aminobenzothieno[2,3-d]pyrimidines

  AUTHORS: Hend Nagah Hafez, Omar Khalid Al-Duaij, Abdel-Rhman Barakat A. El-Gazzar

  KEYWORDS: Spirobenzothienopyrimidine; Triazolopyrimidine; Pyrazolopyrimidine; Analgesic; Anti-inflammatory; Ulcerogenic Effect

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.3 No.2, June 13, 2013

  ABSTRACT: During the last few years, condensed thienopyrimidine derivatives have received considerable attention. The therapeutic importance of thienopyrimidines prompted us to synthesize some of spiro(benzothieno[2,3-d]pyrimidine-4-one) derivatives. Some of the novel benzothino-pyrimidine derivatives 3a, 9b, 10b, 11a, 11b, and 11c showed considerable potent anti-inflammatory and analgesic activity of superior G.I.T. safety profile in experimental rats in comparing to indomethacin and tramadol as reference drugs.