TITLE:
Fatty acids composition of erythrocytes in arterial hypertension associated with dyslipidemia
AUTHORS:
Tatyana P. Novgorodtseva, Yulia K. Karaman, Tatyana A. Gvozdenko, Marina V. Antonyuk, Vera V. Knyshova
KEYWORDS:
Fatty Acids; Arterial Hypertension; Dyslipidemia
JOURNAL NAME:
Health,
Vol.5 No.4A,
April
23,
2013
ABSTRACT:
Studied
the fatty acid (FA) composition of erythrocyte membranes in patients with arterial hypertension associated with
dyslipidemia. The fatty acid composition of
erythrocyte membranes was studied by gaz chromatography. In all hypertensive patients are disturbed lipid FA composition of erythrocytes: increase in
saturated fatty acids (15:0, 16:0), monoenic
fatty acids (18:1n9, 18:1n7), polyunsaturated fatty acids (PUFA) family
n6 (20:4n6), decrease in polyunsaturated fatty acids family n3:22:5n3, 22:6n3,
the total value of n3 PUFA. Cells endogenous deficiency of n3 PUFA leads to the
changes of the plasmatic membranes physicochemical properties, activation of
eicosanoids synthesis with proinflammatory and vasoconstriction activity, the
formation of the systemic inflammatory syndrome and conditions for the
atherogenesis. Thus, structural and functional changes in erythrocyte membranes
in hypertension developed as a part of the common systemic disorder of lipid
metabolism.