TITLE:
Factors Associated with Chronic Kidney Disease in Patients Living with HIV in Yamoussoukro (Ivory Coast)
AUTHORS:
Koffi Christ Ziahy Reine-Marie, Yao Ahua Sébastienne, Gnohité Grâce, Kpan Kéhi Jonathan, Gonan Abdoul Yanick, Affi Mélèdje Césaire, Wognin Manzan Anastasie, Tia Weu Mélanie, Ouattara Bourhaïma
KEYWORDS:
HIV, Chronic Kidney Disease, Screening, Tenofovir
JOURNAL NAME:
Open Journal of Nephrology,
Vol.14 No.4,
December
17,
2024
ABSTRACT: Introduction: Human immunodeficiency virus (HIV) infection is an epidemic in sub-Saharan Africa and is a risk factor for kidney disease. The aim of this study was to assess the prevalence of chronic kidney disease (CKD) in patients living with HIV (PLHIV) in Yamoussoukro and to identify associated factors. Methods: This was a cross-sectional analytical study conducted at the Walè Medical and Social Centre in Yamoussoukro from 4 January to 31 July 2021. The study involved people living with HIV, aged at least 18 years, on Highly active antiretroviral therapy (HAART) protocol, without glomerular filtration rate (GFR) or urine sediment abnormalities, with a complete medical record and having given informed consent. CKD was defined as GFR 2, and/or albuminuria ≥ 30 mg/gCr observed on two assays spaced at least 3 months apart. Data were analysed using Epi-Info software. Results: Of the 174 PLHIV included, 46 were men and 128 were women, giving a sex ratio of 0.4. The mean age was 46.5 years (extremes 19 and 74 years). The majority (96.6%) were infected with HIV-1. The patients were at stage B2 in 36.2% of cases and the mean CD 4 count was 622 cells/ mm3. The first-line treatment regimen included tenofovir disoproxil fumarate (TDF) in 94.3% (164/174). At inclusion, 15 patients (8.6%) had a GFR