Si, Y., Zhang, Z.G., Chen, S.J., Zheng, Y.Q., Chen, Y.B., Liu, Y., et al. (2014) Attenuated TLRs in Middle Ear Mucosa Contributes to Susceptibility of Chronic Suppurative Otitis Media. Human Immunology, 75, 771-776.
https://doi.org/10.1016/j.humimm.2014.05.009

has been cited by the following article:

• TITLE: The Role of Toll-Like Receptors and Nuclear Factor κB p65 Protein in the Pathogenesis of Otitis Media

  AUTHORS: Qingchen He, Yongbo Zhu, Bi Qiang

  KEYWORDS: Otitis Media, Toll-Like Receptors, Nuclear Factor κB p65, Signaling Pathway

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.12 No.10, October 23, 2024

  ABSTRACT: The role of Toll-like receptor 4 (TLR4) and nuclear factor κB p65 (NF-κB p65) proteins in the pathogenesis of otitis media is explored. In recent years, the incidence of otitis media has been rising globally, becoming a significant threat to human health. More and more studies have found that Toll-like receptor 4 (TLR4), as a member of the Toll-like receptor family, can promote the generation of inflammatory factors and is closely related to the body’s immune response and inflammatory response. Nuclear factor-κB p65 (NF-κB p65) is a nuclear transcription factor that can interact with various cytokines, growth factors, and apoptotic factors, participating in processes such as oxidative stress, apoptosis, and inflammation in the body [1]. This article elaborates on the structure, function, and signaling pathways of TLR4 and NF-κB p65 proteins in the pathogenesis of otitis media, aiming to provide more precise targets and better therapeutic efficacy for the diagnosis and treatment of otitis media. The role of inflammation in disease.