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https://doi.org/10.1172/jci.insight.167744

has been cited by the following article:

• TITLE: Neurological Disorders Caused by Structural Dysfunction of VANGL2

  AUTHORS: Liheng Shen, Zixiang Xu, Xiaobin Xiong, Xin Sheng

  KEYWORDS: VANGL2, Neurological Disorders, Planar Cell Polarity (PCP) Pathway, Neural Tube Defects

  JOURNAL NAME: Neuroscience and Medicine, Vol.15 No.2, July 3, 2024

  ABSTRACT: Background: VANGL2 plays a variety of roles in various cellular processes, including tissue morphogenesis, asymmetric cell division, and nervous system development. There is currently a lack of systematic organization in the development and disease of the nervous system. Purpose: To explore the role of VANGL2 in the development of the nervous system and related diseases. Methods: Literature review and analysis of the role of VANGL2 in the development and disease of the nervous system. Results: VANGL2 defects lead to the development of the nervous system through the misconfiguration of various cells, which affects the development of the cochlea, the conduction of neural signals, and the development of nervous system-related diseases such as Alzheimer’s disease, GBM, Bohling-Opitz syndrome, and hydrocephalus. Conclusions: The VANGL2 gene is essential for nervous system development and its deficiency is linked to severe congenital conditions and various disorders, highlighting the need for more research on treatments for related gene defects.