Lubova, K.I., Chugunov, A.O., Volynsky, P.E., Trofimov, Y.A., Korolkova, Y.V., Mosharova, I.V., Kozlov, S.A., Andreev, Y.A. and Efremov, R.G. (2020) Probing Temperature and Capsaicin-Induced Activation of TRPV1 Channel via Computationally Guided Point Mutations in Its Pore and TRP Domains. International Journal of Biological Macromolecules, 158, 1175-1183.
https://doi.org/10.1016/j.ijbiomac.2020.04.239

has been cited by the following article:

• TITLE: Chemesthesis Pain Reduction from Capsaicin and/or Allyl Isothiocyanate (AITC) When Introducing Humulene and Myrcene

  AUTHORS: Curtis H. Breville

  KEYWORDS: TRPM8, TRPV1, TRPA1, Humulene, Myrcene, Capsaicin, Allyl Isothiocyanate, Sensation, Hops, Spice, Cooling, Burning

  JOURNAL NAME: Open Access Library Journal, Vol.11 No.4, April 30, 2024

  ABSTRACT: The pain experienced when eating spicy foods such as peppers, wasabi, horseradish, or spicy mustard come from particular natural compounds binding to specific receptors in our mouth on nerve endings communicating with the sensory cortex. When concentrated, compounds humulene and myrcene, both existent in different ratios in varieties of hops (Humulus lupulus), bind to the TRPM8 receptor. While bound to this receptor at the same time as either capsaicin is bound to the TRPV1 receptor or allyl isothiocyanate (AITC) is bound to the TRPA1 receptor, the pain from the TRPV1 and TRPA1 is severely reduced or eliminated. Test subjects have volunteered to test the efficacy of the humulene & myrcene concentrate through both formalized controlled environment experiments as well as informal field sample efficacy demonstrations on social media.