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https://doi.org/10.1097/WNR.0000000000000553

has been cited by the following article:

• TITLE: The Influence of Remote Ischemic Conditioning on Focal Brain Ischemia in Rats

  AUTHORS: Maria E. Kolpakova, Anastasia A. Yakovleva, Ludmila S. Polyakova

  KEYWORDS: Stroke, Brain Infarction, Ischemia-Reperfusion, Syndecan-1, Glycocalyx, Endothelial Dysfunction, Middle Cerebral Artery Occlusion (MCAO), Remote Ischemic Conditioning (RIC)

  JOURNAL NAME: Journal of Behavioral and Brain Science, Vol.11 No.6, June 23, 2021

  ABSTRACT: Despite obvious progress in the treatment of acute forms of ischemic stroke, the risk of this condition remains unacceptably high. Brain infarction in the middle cerebral artery basin occurs in patients with atherosclerosis. The onset of the brain infarction is facilitated by the cessation of circulation (embolism) in conditions of insufficient collateral circulation. The extent of the infarct zone is determined by neuronal death and impaired microcirculation. The development of new methods for effective targeted restorative stroke therapy is crucial for restorative treatment and reducing the risk of mortality after stroke. Remote ischemic conditioning (RIC) is an approach to limiting reperfusion injury in the ischemic region of the brain after focal ischemia. One of the most commonly used in vivo models in stroke studies is the filament model of Middle Cerebral Artery Occlusion (MCAO) in rats. In our experiment, it was performed for 30 min (J. Koizumi) with subsequent 48-hour reperfusion. Within the first 24 hours after the start of reperfusion several short episodes of ischemia in low limbs were induced. After 48 hours of reperfusion the brains were harvested and stained with TTC. Then we evaluated the effect of RIC within 24 hours ex vivo in rats’ brains, as well as syndecan-1 plasma concentration. Infarct area was assessed by means of Image-Pro program with statistical analysis. Infarct volumes in the model group (31.97% ± 2.5%) were significantly higher compared to the values in the RIC group 48 hours after ischemia-reperfusion (13.6% ± 1.3%) (*P