TITLE:
Nrf-2 and HO-1 Expression in Medulloblastoma: A Clinicopathological Analysis
AUTHORS:
Li Tang, Yu Deng, Minna Gao, Xiao Lin, Jin Zhu, Yu Li
KEYWORDS:
Medulloblastoma, Nrf-2, HO-1, Immunohistochemistry
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.5 No.3,
March
31,
2017
ABSTRACT:
Medulloblastoma (MB) is one of the most common malignant tumors with poor survival in children. Nuclear factor erythroid 2-related factor2 (Nrf-2) and heme oxygenase-1 (HO-1) have been considered to play major roles in the pathogenesis of many tumors. There is no report about clinicopathological significance of Nrf-2 and HO-1 expression in medulloblastoma. In the present study, to explore the expression and potential function of Nrf-2 and HO-1 in MBs, immunohistochemistry was used to examine the Nrf-2 and HO-1 expression in 41 MBs and 27 control tissues adjacent to the tumor. The results showed that in the cases of MB, the positive expression rates of Nrf-2 and HO-1 (82.9% and 78.0%) were significantly increased compared with that (37.0% and 29.6%) in peritumoral control brain tissues. The difference was statistically significant (P 0.05). The abnormal expression of Nrf-2 and HO-1 in MB suggest that the Nrf-2/HO-1 pathway plays an important role in the formation and development of MB and may be a potential therapeutic target for MB.