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has been cited by the following article:

• TITLE: Diversity of the RNA Polymerase in the H7N9 Influenza A Virus

  AUTHORS: Jing Li, Wenjun Liu

  KEYWORDS: Diversity, RNA Polymerase, H7N9 Influenza A Virus

  JOURNAL NAME: Advances in Microbiology, Vol.5 No.9, August 27, 2015

  ABSTRACT: A novel influenza virus of the H7N9 subtype has infected more than 350 people in China since 19 February 2013. Evolutionary analysis indicates that the virus is a reassortant originated from H7, N9 and H9N2 avian influenza viruses, and bears some amino acids associated with mammalian receptor binding, raising concern over the possibility of a new influenza pandemic. Besides HA and NA, the mutation of the polymerase is known to have an important role in virulence, host adaptation and transmissibility in mammalians. In this article, the annotation of the polymerase protein domain associated with molecular function has been highlighted, suggesting the combination of RNA polymerase of H7N9 viruses is still not stable for host adaptation. In addition, the mutation hallmarks in polymerase gene of H7N9 are compared, providing the potential determinants of the evolution in the H7N9 influenza A virus.