TITLE:
Theory of cold denaturation of proteins
AUTHORS:
Arieh Ben-Naim
KEYWORDS:
Protein Folding; Cold Denaturation; Hydrophobic; Hydrophilic Effects
JOURNAL NAME:
Advances in Biological Chemistry,
Vol.3 No.1,
February
17,
2013
ABSTRACT:
A new approach to the problem of cold denaturation
is presented. It is based on solvent-induced effects operating on hydrophilic
groups along the protein. These effects are stronger than the corresponding
hydrophobic effects, and they operate on the hydrophilic groups which are
plentiful than hydrophobic groups. It is shown that both heat and cold denaturation can be explained by these hydrophilic effects.