TITLE:
Neuro-Cognitive Functions in ALL Childhood Cancer Survivors in NCI, Cairo University, Egypt
AUTHORS:
Menna Shamma, Ahmed Kamel, Doaa R. Ayoub, Mohamed H. Fawzy
KEYWORDS:
Acute Lymphoblastic Leukemia, Neuro-Cognitive Functions, Child Behavior Checklist, Chemotherapy, Wechsler Intelligence Scale
JOURNAL NAME:
Open Access Library Journal,
Vol.9 No.10,
October
24,
2022
ABSTRACT: Objective: Acute Lymphoblastic Leukemia (ALL) is one of the most common childhood malignancies, accounting for about 75% of all leukemias and a quarter all of childhood cancers, in this research we aimed at assessing neuro-cognitive consequences in children with Acute Lymphoblastic Leukemia who have been treated with chemotherapy. Methods: 95 children aged between 6 and 12 years old completed Wechsler Intelligence Scale for Children (WISC III). Sixty-one children were ALL survivors at the Pediatric Oncology Department, NCI, Cairo University compared to thirty-four were control group consisted of matching children from the same age group. Study patients have successfully accomplished their treatment protocol and were in complete remission during the evaluation for ≥ 2 years under follow up without relapse and no prediagnosis history of neuro-developmental disorder nor psychiatric disorders as evidenced by Child Behaviour Checklist (CBCL). Results: Subjects scored significantly below levels for their matched controls. The difference between patients and controls was significant (p Conclusions: Long-term sequels in neuro-cognitive functions were found in the chemotherapy only group, female patients were at higher risk than males; observed in the impairments of memory, attention, logical thinking and social knowledge.