TITLE:
Correlation of Inflammatory Cells in Induced Sputum and Peripheral Blood of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease
AUTHORS:
Xin Wang, Di Wu, Yanmei Wu, Hongyan Liu, Ying Wang, Chunmei Yun, Dejun Sun, Xiaoyu Gao
KEYWORDS:
Chronic Obstructive Pulmonary Disease, Induced Sputum, Peripheral Blood, Inflammatory Cells
JOURNAL NAME:
Open Journal of Respiratory Diseases,
Vol.11 No.3,
August
27,
2021
ABSTRACT: Chronic obstructive pulmonary disease (COPD) is a major chronic respiratory disease worldwide. Inflammatory
cells reflect the inflammatory situation both in
peripheral blood and induced sputum. Their correlation has not been reported. The correlation between
neutrophils (Neu), eosinophils (Eos), and lymphocyte (Lym) in induced sputum
and that in peripheral blood of COPD patients
was evaluated to explore
the consistency of inflammatory cells in peripheral blood
and induced sputum. Peripheral blood and induced sputum were collected from 437 patients
with acute exacerbation of COPD (AECOPD) who
were hospitalized in the Department of respiratory and critical care medicine,
Inner Mongolia People’s Hospital. The correlation
analysis was performed by Spearman correlation analysis. The
ratios of Neu,
Eos, and Lym in induced sputum were (79.15 ± 22.60)%, (5.23 ± 12.74)%, and
(1.69 ± 2.66)%. The ratios of Neu, Eos, and Lym in peripheral blood were (63.29 ± 11.44)%, (2.99 ± 3.60)%, and (25.16 ± 10.19)%. The results
showed that the ratios of Neu and Eos in induced sputum were significantly
correlated with the proportion of corresponding cells in peripheral blood (P There was no correlation between the ratio of
Lym and Leu in induced sputum and corresponding cells in peripheral
blood (P > 0.05). In patients with AECOPD, the
tendency of Neu and Eos in induced sputum was consistent with the
corresponding cells in peripheral blood. Neu and Eos in induced
sputum and peripheral blood reflected the degree of inflammation to
guide the individualized medication of patients.