Dr. Kunihiro Sakuma

Toyohashi University of Technology, Japan

Email: ksakuma@las.tut.ac.jp

Qualifications

1993-1996  Doctral program, University of Tsukuba

1991-1993  Master program, University of Tsukuba

1987-1991  Under graduate program, University of Tsukuba

Publications (Selected)

1. Sakuma K, Yamaguchi A: Sarcopenia: Molecular mechanisms and current therapeutic strategy. Eds. Perloft JW and Wong AH, In: Cell Aging (in press), Nova Science Publishers, NY, 2011.
2. Sakuma K, Yamaguchi A: Serum response factor(SRF)-dependent pathway: Potential mediators of growth, regeneration, and hypertrophy of skeletal muscle. Eds. Pandalai S, In; Recent Research Developments in Life Science (in press), Research Signpost, Kerala, India, 2011.  
3. Sakuma K, Yamaguchi A: Calcineurin-dependent signaling: potent regulators for fiber-type transformation, regeneration, and hypertrophy of skeletal muscle. Eds. Sakuma K, In: Current Research Trends in Skeletal Muscle (in press), Research Signpost, Kerala, India, 2011.
4. Yamaguchi A, Sakuma K, Morita I: Local and circulating insulin-like growth factor-I on skeletal muscle. Eds. Sakuma K, In: Current Research Trends inSkeletal Muscle (in press), Research Signpost, Kerala, India, 2011.
5. Sakuma K, Yamaguchi A: Molecular determinants of skeletal muscle hypertrophy. Journal of Sports Medicine & Doping Studies, in press, 2011.
6. Sakuma K, Yamaguchi A: Sarcopenia and cachexia: the adaptations of negative regulators of skeletal mass. J Cachexia Sarcopenia Muscle, in press.
7. Sakuma K, Yamaguchi A: Novel intriguing strategies attenuating to sarcopenia. J Aging Res, Article ID 251217, in press.
8. Sakuma K, Yamaguchi A: Current application of cyclosporine A to investigate skeletal muscle adaptation. Curr Enzyme Inhibit, in press, 2011.
9. Aoi W, Sakuma K: Oxidative stress and skeletal muscle dysfunction with aging. Curr Aging Sci 4, 101-109, 2011.
10. Sakuma K, Yamaguchi A: The recent understanding of the neurotrophin's role in skeletal muscle adaptation. J Biomed Biotechnol 2011, Article ID 201696, 12 pages.
11. Sakuma K, Yamaguchi A: Inhibitors of myostatin- and proteasome- dependent signaling for attenuating muscle wasting. Recent Pat Regen Med 1: 284-298, 2011.
12. Sakuma K, Yamaguchi A: The functional role of calcineurin in hypertrophy, regeneration, and disorders of skeletal muscle. J Biomed Biotechnol 2010: Article ID 721219, 8 pages, 2010.
13. Sakuma K, Yamaguchi A: Molecular mechanisms in aging and current strategies to counteract sarcopenia. Curr Aging Sci 3: 90-101, 2010.
14. Sakuma K, Yamaguchi A: Cyclosporin A inhibits the growth of neonatal MHC-expressing myotubes independent of NFATc1 and NFATc3 in the mechanically overloaded soleus muscle of mice. Am J Mol Biol 1: 7-16, 2011.
15. Hokari F, Kawasaki E, Sakai A, Koshinaka K, Sakuma K, Kawanaka K: Muscle contractile activity regulates Sirt3 protein expression in rat skeletal muscles. J Appl Physiol 109: 332-340, 2010.
16. Akiho M, Nakashima H, Sakata M, Yamasa Y, Yamaguchi A, Sakuma K : Expression profile of Notch-1 in mechanically overloaded plantaris muscle of mice. Life Sci 86: 59-65, 2010.
17. Sakuma K, Watanabe K, Hotta N, Koike T, Ishida K, Katayama K, Akima H : The adaptive responses in several mediators linked with hypertrophy and atrophy of skeletal muscle after lower limb unloading in humans. Acta Physiol (Oxf) 197: 151-159, 2009.
18. Tokugawa S, Sakuma K, Fujiwara H, Hirata M, Oda R, Morisaki S, Yasuhara M, Kubo T: The expression pattern of PKCtheta in satellite cells of normal and regenerating muscle in the rat. Neuropathology 29: 211-218, 2009.
19. Sakuma K, Akiho M, Nakashima H, Akima H, Yasuhara M : Age-related reductions in expression of serum response factor and myocardin- related transcription factor A in mouse skeletal muscles. Biochim Biophys Acta Mol Basis Dis 1782: 453-461, 2008.
20. Sakuma K, Akiho M, Nakashima H, Nakao R, Hirata M, Inashima S, Yamaguchi A, Yasuhara M : Cyclosporin A modulates cellular localization of MEF2C protein and blocks fiber hypertrophy in the overloaded soleus muscle of mice. Acta Neuropath (Berl) 115: 663-674, 2008.

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