TITLE:
Lymphocytosis in Idiopathic Thrombocytopenic Purpura Patients Infected by Helicobacter pylori
AUTHORS:
Naoki Takezako, Naohiro Sekiguchi, Akira Tanimura, Chiho Homma, Tateki Shikai, Yayoi Takezako, Noboru Yamagata, Akiyoshi Miwa
KEYWORDS:
Idiopathic Thrombocytopenic Purpura; Helicobacter pylori; Eradication; Lymphocytosis; Helper Th1 Lymphocyte
JOURNAL NAME:
Open Journal of Blood Diseases,
Vol.3 No.1,
March
29,
2013
ABSTRACT:
Background and Objectives: Several recent
reports have demonstrated a close linkage between idiopathic thrombocytopenic purpura (ITP) and Helicobacter pylori (H. pylori) infection in some
patient’s populations. However, the pathogenetic mechanisms of H. pylori-induced thrombocytopenia
remain obscure. Therefore, we investigated the prevalence of H. pylori infection pylori and performed
a comparative analysis of a subset of H.
pylori-infected patients (group A) with non-infected patients (group B)
using the standard statistical methods. Design and Methods: From December
2001 to October 2002, we investigated the presence of gastric H. pylori infection in 30 adult ITP
patients and 19 patients
were treated with standard antibiotic therapy for H. pylori eradication (amoxicillin and clarithromycin plus lansoprazole combination). We used the
standard statisticsto analyze the difference between group A and group B. Results: H. pylori eradication was achieved in 17/19 (89.4%) H.pylori-infected
patients. An improvement of platelet count was observed in 14/19 patients
(73.6%) who achieved the eradication. Five of these patients achieved CR (two
patients were with the acute ITP) and nine patients reached PR. The difference
between the mean platelet count ± S.D. before and after H. pylori therapy was statistically
significant in patients with successful decontamination (65 ± 48 × 109/L vs. 200 ± 140 × 109/L; p = 0.018). Lymphocyte counts at the
diagnosis of H. pylori infected cases
were significant higher than those of non-infected cases (1.58 ± 0.13 × 109