TITLE:
N-Butylpyridoquinoxaline 1,4-dioxide (NBPQD) as a new potent for tumor imaging and therapy
AUTHORS:
Salem A. Habib, Ismail T. Ibrahim, Mohamed A. Abd-Eldaye, Mamdouh M. El-Sheshtawey, Heba M. Waly
KEYWORDS:
Ehrlich Ascites Carcinoma; SOD; MDA; 125I-NBPQD; GSH-R; GSH
JOURNAL NAME:
Natural Science,
Vol.4 No.12,
December
24,
2012
ABSTRACT: The development of new and effective antitumor agents is one of the main goals of medicinal and biochemical research at present. The present study is concerned with the evaluation of the previously synthesized N-Butylpyridoquinoxaline 1,4-dioxide (NBPQD) as an antitumor agent against Ehrlich ascites carcinoma (EAC). The first part of the study (tumor imaging) was to investigate the biodistribution of NBPQD in the organs of EAC-bearing mice using iodine-125 isotope stressing on its distribution in the main organs (stomach, liver, spleen, kidney) in addition to blood and ascetic fluid. The second part was the assessment of the antitumor activity of NBPQD by estimating the tumor volume and the contents of total protein, total lipid, DNA and RNA in liver tissues. In addition, liver function tests and the redox status were assessed. Tumor volume and DNA, RNA, urea and malondialdehyde (MDA) levels and the liver enzymes activity were highly significantly increased (P