TITLE:
Congenital Cytomegalovirus Infection and Maternal Varicella during Pregnancy. Is There a Coincidence? A Case Report
AUTHORS:
Claire Périllaud-Dubois, Elise Bouthry, François-Charles Javaugue, Alexandra Letourneau, Aurore Bonnin, Emmanuelle Letamendia, Christelle Vauloup-Fellous
KEYWORDS:
cCMV, VZV, Intercurrent Infection, Asymptomatic Congenital CMV Infection
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.9 No.9,
September
6,
2019
ABSTRACT: Background: Co-infections may represent substantial diagnostic and treatment
challenges. Aim: To the better of our knowledge, we describe the first
case in the literature of congenital Cytomegalovirus (CMV) infection following
maternal CMV non primary infection contemporary to varicella during pregnancy. Case
Presentation: A pregnant woman had a varicella during her pregnancy.
Congenital CMV infection was fortuitously discovered in the neonate owing to a
universal CMV screening. Retrospective analysis of maternal serums during
pregnancy showed CMV reactivation. We aim to highlight that CMV reactivation
could be due to varicella and discuss if it could facilitate the transplacental
transmission of CMV. Conclusion: This case report emphasizes neonatal
CMV screening, and warns against dual maternal infection especially because
this may be at particular risk of transmission to the fetus.