TITLE:
Synthesis and Determination of Antitumor Activity of Jacaranone and Synthetic Analogs
AUTHORS:
María L. Arias, Eugenia Corrales, Rebeca Poveda, Jorge A. Cabezas
KEYWORDS:
Jacaranone, Jacaranone Synthetic Analogs, Antitumor Activity
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.8 No.1,
March
7,
2018
ABSTRACT: Natural product jacaranone, 1, and three
analog derivatives were synthesized and their apoptotic and necrotic activity
against four cancer cell lines was tested. One of these derivatives 7,
was more active than the natural product, and exhibited an important necrotic
effect against three of the cell lines tested (ovarian carcinoma, liver cancer
and breast cancer cells). Derivative 6 was more active than the natural
product, and showed a significant apoptotic activity against breast cancer and
ovarian carcinoma cells. Some derivatives analyzed in this study showed
promising anti-tumor results, nevertheless, further studies have to be done in
order to determine their in vivo activity, their mechanism as well as their safety and stability.