TITLE:
Relationship between C-Reactive Protein, White Blood Cell Count and Metabolic Syndrome in Nigerians with Type 2 Diabetes Mellitus
AUTHORS:
D. O. Soyoye, R. T. Ikem, B. A. Kolawole, R. A. Bolarinwa, O. O. Amjo, O. T. Yusuff, F. A. Owolabi, O. O. Ezekpo
KEYWORDS:
C-Reactive Protein, Inflammatory Markers, Metabolic Syndrome, Type 2 Diabetes Mellitus
JOURNAL NAME:
Journal of Diabetes Mellitus,
Vol.7 No.3,
August
30,
2017
ABSTRACT: Background: Presence of metabolic syndrome (MS) in people with diabetes confers
increased cardiovascular and diabetes-specific micro- and
macrovascular complications. The pathogenic pathways for metabolic syndrome are
still issues for discussion especially in some special groups like those with
type 2 diabetes mellitus (T2DM). Recent evidences suggest that inflammation may
play a key role in MS. This study assessed the relationship between MS (and its
component risks) and markers of inflammation (high-sensitivity C-reactive
protein {hs-CRP} and white blood cells {WBC}). Methods: A cross-sectional study involving 108 patients with T2DM. Anthropometric
measurements and clinical examination were conducted. Blood sample was
collected for hs-CRP, WBC, glycated haemoglobin etc. Metabolic syndrome was
defined using the International Diabetes Federation criteria. Ethical approval
was granted and informed consent was obtained from participants. Results: Mean age of male and female participants were 58.00
± 7.01 years and 55.48 ± 8.35 years respectively (p = 0.092). Eighty-two (75.9%)
participants had metabolic syndrome. Median values of hs-CRP and total WBC were
0.89mg/L and 5.73 x103/mm3 respectively. On correlation,
hs-CRP showed statistically significant association with waist circumference (r
= 0.194; p = 0.044), fasting plasma glucose (r = 0.191; p = 0.048) and serum
triglycerides (p = 0.226; r = 0.019). There was no statistically significant association between WBC and the metabolic
components. Conclusion: Prevalence of metabolic syndrome is high, and C-reactive protein was associated with waist circumference, fasting plasma
glucose and serum triglycerides.