TITLE:
EMT and Anti-EMT Strategies in Cancer
AUTHORS:
M. A. Nezami, Steven Hager, Jessica Garner
KEYWORDS:
Cancer, EMT, Anti-EMT, Epigenetic, CTC, ctDNA
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.6 No.11,
October
29,
2015
ABSTRACT: This article discusses the role of epithelial mesenchymal transition (EMT)
and addresses the scientific merits on epigenetic regulation of EMT. The importance
of EMT as a prognostic biomarker is explored and the rationale on application of
multitargeted epigenetic therapy is discussed. We describe a literature review of
the epigenetic influence of such process and we present a potentially effective
method to reverse the epigenetic switch in favor for MET, in a clinical setting.
A case series of advanced solid tumors are summarized aiming at generating hypothesis
for the future recommendations for clinical trials targeting the tumor’s biological
behavior through inhibition of EMT. Hypothesis: We propose an integral and integrative
approach that can modify tumor’s biological behavior through inhibition of EMT,
and further reduce the chances of metastasis, that can translate to improved outcome
and patient’s survival in advanced disease.