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has been cited by the following article:

• TITLE: Synthesis, Reactions and Antimicrobial Activity of Some New 3-Substituted Indole Derivatives

  AUTHORS: Asmaa S. Salman, Naema A. Mahmoud, Anhar Abdel-Aziem, Mona A. Mohamed, Doaa M. Elsisi

  KEYWORDS: Indole-3-Carboxaldehyde, Acid Hydrazide, 1, 3-Thiazole, Pyrimidine, Antimicrobial

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.5 No.2, June 10, 2015

  ABSTRACT: Reaction of indole-3-carboxaldehydes 4 with hydrazine derivatives and different substituted acid hydrazides afforded the corresponding hydrazine derivatives 5a-c and acid hydrazide derivatives 7-11 respectively. Condensation of indole-3-carboxaldehydes 4 with phenacyl bromide and thiourea gives 1,3-thiazol-2-amine derivative 18. On the other hand, reaction 4 with 3-acetylchromene-2-one afforded chalcone derivative 19. Compound 4 undergoing Knoevenagel condensation with cyanoacetamide, ethyl cyanoacetate, benzimidazol-2-ylacetonitrile, rhodanine-3-acetic acid, 2,3-dihydropyrimidin-4-one derivative and 2,4-dihydropyrazol-3-one afforded the compounds 20a,b, 22, 23, 27 and 28 respectively. The structure of the newly synthesized compounds has been confirmed by elemental analysis and spectra data. The antimicrobial activities of the some newly synthesized compounds were measured and showed that most of them have high activities