TITLE:
The Association between Autosomal Dominant Polycystic Kidney Disease and Renal Cell Carcinoma
AUTHORS:
Chase C. Hansen, Michael Derrick, Irfan Warriach, James Thomas Cammack, James Thomas Cammack, Werner de Riese
KEYWORDS:
Autosomal Dominant Polycystic Kidney, Chronic Kidney Failure, Genetic Variation, Nephrectomy, Renal Cell Carcinoma
JOURNAL NAME:
Open Journal of Urology,
Vol.5 No.6,
June
5,
2015
ABSTRACT: Objectives: The relationship between
autosomal dominant polycystic kidney disease (ADPKD) and renal cell carcinoma
(RCC) is investigated to determine a link that would guide management due to
elevated RCC risk. Current literature is inconclusive on this topic. Methods:
This study is a retrospective chart review of patients having undergone
nephrectomy. Those with pathology and history consistent with ADPKD were
reviewed for presence of RCC. Results: The review at this institution revealed
RCC in 18% of ADPKD patients who underwent nephrectomy. These rates are
significantly higher than those found in the general population, and even
greater than those would be expected in patients suffering end-stage renal
disease (ESRD). Conclusions: Due to the increased prevalence of RCC in ADPKD,
clinicians managing patients with ADPKD should maintain a high index of
suspicion. Our data suggest a link between ADPKD and RCC, most likely at the
genetic level. In light of this, we feel that further genetic research is
needed to potentially discover the link between these two disease processes.