TITLE:
Caboxymetylcellulose/Gelatin Blends Loaded with Piroxicam: Preparation, Characterization and Evaluation of in Vitro Release Profile
AUTHORS:
Vivia Buzzi, Marli Brudner, Theodoro Maciel Wagner, Giovana C. Bazzo, Ana Paula Testa Pezzin, Denise Abatti Kasper Silva
KEYWORDS:
Piroxicam; Gelatin; Carboxymethyl Cellulose
JOURNAL NAME:
Journal of Encapsulation and Adsorption Sciences,
Vol.3 No.4,
December
6,
2013
ABSTRACT:
Piroxicam is a non-steroidal anti-inflammatory drug
(NSAID) exhibiting analgesic and antipiretic properties and widely used in the
management of chronic diseases. Associated with these use, there
are registers of adverse reactions. Microparticle formulations in hydrogel matrix can be
used to form a semi-permeable barrier which enables their actions and can
reduce the effects. This work presents a study on the effect of
gelatin/carboxymethyl cellulose (Gel/CMC) semi-IPN matrix composition on the
retention and kinetic behavior of releasing this drug. The microparticles were
obtained through the emulsion-crosslinking method using 23 factorial planning and the piroxicam was added as solid particles.
In order to characterize the interaction between matrix-active
agent and quantification of the drug, the following techniques were applied:
SEM, DSC and XRD. SEM micrographs
revealed microparticles with regular and spherical shape and that in some compositions the drug is partially absorbed and not encapsulated. Beyond that DSC and XRD analyses indicate
that the piroxicam remained in the matrixes, maintains the same crystalline form. The
factorial planning analysis indicated that matrix obtained a maximum
encapsulation efficiency (EE%) of 10.64% and became possible to create a response surface graph using
a EE% as answer. In addition to this, release kinetics analyses demonstrated
that the release process seems to be governed by
distinctly kinetic models, considering the composition of the sample. In some samples the release can be driven by Fickinianan diffusion, others by anomalous transport or
swelling.