University of Cincinnati, USA

Professor

E mail: khhaider@gmail.com

Qualifications

1993 Ph.D., University of Strathclyde, Glasgow, UK

1985 M.Pharmacy, University of the Punjab, Lahore-Pakistan

1983 B.Pharmacy, University of the Punjab, Lahore-Pakistan

1978 B.S., University of the Punjab, Lahore-Pakistan

Publications (selected)

1. Kim HW, Malik F, Durrani S, Ashraf M, Jiang S, Haider HKh. The miR-107/ PDCD10 mediated cytoprotection of stem cells is independent of hypoxamir-210 during ischemic preconditioning. Antiox Redox Sig, 2012 April.
2. Khach Lai V, Ashraf M, Jiang S, Haider HKh. MicroRNA-143 is critical regulator of cell cycle activity in stem cells with co-overexpression of Akt and angiopoietin-1 via transcriptional regulation of Erk5/Cyclin D1 signaling. Cell Cycle, 2012, 11(4), 667-77.
3. Niagara MI, Jiang S, Ashraf M, Haider HKh. Activation of IL11/STAT-3 pathway by preconditioning blocks apoptotic cascade in human skeletal myoblasts under oxidant stress. Regene Med. 2012, 7(1), 47-57.
4. Kach Lai V, Afzal MR, Ashraf M, Jiang S, Haider HKh. Non-hypoxic stabilization of Hif-1α during coordinated interaction between Akt and angiopoietin-1 enhances endothelial commitment of bone marrow stem cells.J Mol Medicine. 2012 January.
5. Kim HW, Ashraf M, Jiang S, Haider HKh.Stem cell based delivery of miR-210 and its transfer to the host cardiomyocytes via gap junctions promotes cardiac functional recovery. J Mol. Medicine, 2012.
6. Lu G, Ashraf M, Haider HKh. IGF-1 preconditioning accentuates intrinsic survival mechanism in stem cells to resist ischemic injury by orchestrating PKCα-MAPK activation. Antiox Red Sig., 2012, 16(3), 217-227.
7. Durrani S, Haider HKh, Ahmed RPH, Jiang S, Ashraf M. Cytoprotective and proangiogenic activity of Netrin-1/Unc5b ligand/receptor interaction: netrin-1 transgene delivery protects the heart against ischemia/reperfusion injury. Stem Cells Dev Nov. 2011.
8. Ahmed RPH, Haider HKh, Buccini S, Shujia J, Ashraf M. Reprogramming of skeletal myoblasts for induction of pluripotency for tumor free cardiomyogenesis in the infarcted hear. Circ Res. 2011; 109, 60-70.
9. Ye L, Zhang W, Su L-P, Haider HKh, Poh KK, Galupo MJ, Songco G, Ge R-W, Tan H-C, Sim EKW. Nanoparticle based delivery of hypoxia-regulated VEGF transgene system combined with myoblast engraftment for myocardial repair. Biomaterials. 2011, 32: 2424-2431.
10. Igura K, Haider HKh, Ahmed RPH, Sheriff S, Ashraf M. Neuropeptide-Y (NPY) and NPY Y5 receptor (Y5R) interaction restores impaired growth potential of ageing bone marrow stromal cells. Rejuven Res. 2011, 14(4): 393-403.
11. Durrani S, Konoplyannikov M, Ashraf M, Haider HKh. Skeletal myoblasts for cardiac repair (mini-review). Regen Med. 2010, 5(6): 919-932.
12. Lu G, Haider HKh, Porollo A, Ashraf M. Mitochondria specific transgenic overexpression of connexin-43 simulates preconditioning induced cytoprotection of stem cells. Cardiovasc Res. 2010, 88: 277-286.
13. Haider HKh, Buccini S, Ahmad RPH, Ashraf M. de novo Myocardial regeneration: advances and pitfalls. Antiox Redox Sig, 2010, 13(12), 1867-77.
14. Ahmed RPH, Haider HKh, Jiang S, Rizwan Afzal MR, Ashraf M. Sonic hedgehog gene delivery to the rodent heart promotes angiogenesis via iNOS/Netrin-1/PKC pathway. PLoS ONE2010; 5(1): e8576.
15. Haider HKh, Idris NM, Ha Won Kim HW, Ahmed RP, Jinag S, Ashraf M. MicroRNA-21 is a key determinant in IL11/STAT-3 anti-apoptotic signaling pathway in preconditioning of skeletal myoblasts. Cardiovasc Res. 2010, 88: 168-78.
16. Kim HW, Haider HKh, Jiang S, Ashraf M. Ischemic preconditioning augments survival of stem cells via miR-107 and miR-210 expression. J Biol Chem. 2009; 284: 33161-8.
17. Lu G, Haider HKh, Jiang S, Ashraf M. Dual role of connexin-43 in cytoprotection and enhanced engraftment in IGF-1 preconditioned Sca-1+cells. Circulation2009; 119(19): 2587-96.
18. Haider HKh, Jiang S, Niagara MI, Ashraf M. IGF-I over expressing mesenchymal stem cells accelerate bone marrow stem cell mobilization via paracrine activation of SDF-1α/CXCR4 signaling to promote myocardial repair. Circulation Res.2008; 103: 1300-1308.
19. Lei Y, Haider HKh, Tan RS, Su LP, Law PK, Zhang W, Sim EKW. Angiomyogenesis using liposome based vascular endothelial growth factor-165 transfection with skeletal myoblast for cardiac repair. Biomaterials. 2008; 29(13): 2125-37.
20. Jiang S, Khawaja Husnain Haider, Niagara MI, Lu G, Ashraf M. Stable therapeutic effects of mesenchymal stem cell based multiple gene delivery for cardiac repair. Cardiovasc Res. 2008; 77(3): 525-33.
21. Lei Y, Haider HKh, Toh WC, Beng W, Tan R, Law PK, Su L, Ge R, Zhang Y, Sim EKW. Transplantation of nanoparticle based skeletal myoblasts over-expression vascular endothelial growth factor-165 for cardiac repair. Circulation2007; 116; I-113-I-120.
22. Niagara MI, Haider HKh, Jiang S, Ashraf M.Pharmacological preconditioning renders skeletal myoblasts resistant to oxidative stress and enhances their cardiac repair ability via expression of paracrine factors after transplantation. Circulation Res.2007; 100: 545-555.
23. Jiang S, Haider HKh, Niagara MI, Salim A, Ashraf M. Supportive interaction between cell survival signaling and angio-competent factors enhances donor cell survival and promotes angiomyogenesis for cardiac repair. Circulation Res. 2006; 99: 776-784.
24. Lei Y, Khawaja Husnain Haider, Jiang S, Tan R-S, Ge R, Law PK, Sim EKW. Improved angiogenic response in pig heart following ischemic injury using human skeletal myoblast simultaneously expressing VEGF165and angiopoietin-1. Eur J Heart Fail.2007; 9(1): 15-22.
25. Lei Y, Khawaja Husnain Haider, Jiang S, Tan RS, Ge R, Law PK, Sim EKW. Angiopoietin-1 induced myocardial neovascularization: a comparison between ex-vivo delivery using skeletal myoblasts vs direct viral vector injection. Eur J Heart Failure2007; 9: 458-65.