Dr. Peizhong Mao
Department of
Physiology & Pharmacology, School of Medicine
Oregon Health & Science
University (OHSU), Portland, Oregon, USA
E-mail: maop@ohsu.edu
Qualifications
1995-1999 Ph.D., molecular biology, Laboratory
of Gene Regulation, Institute for Genetic Medicine, Hokkaido
University (Japan)
1985-1988 Master Degree, Physiology, Jiangxi
Traditional Chinese Medical College (China)
1980-1985 M.D. (equal), Hebei Medical University
(China)
Publications (Selected)
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Mao P, Manczak M,
Shirendeb UP, Reddy PH. MitoQ, a mitochondria-targeted antioxidant, delays
disease progression and alleviates pathogenesis in an experimental
autoimmune encephalomyelitis mouse model of multiple sclerosis.Biochim
Biophys Acta. 1832(12): 2322-2331, 2013.
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Mao P, Meshul C,
Thuillier P and Reddy PH. Neuropeptide CART as a therapeutic
candidate for Parkinson’s disease. Pharmaceuticals (Basel). 2013
Jan 18; 6(1). doi:pii: 108.
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Mao P. Oxidative
stress and its clinical applications in dementia. Journal
of Neurodegenerative Diseases, Article ID 319898,
doi:10.1155/2013/319898, 2013.
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Mao P. Recent
progress and concerns in dementia: distinguishing Alzheimer’s disease and dementia
with Lewy bodies via biochemical markers in the cerebrospinal fluid. Advances
in Biological Chemistry, 2(2): 176-190, 2012.
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Mao P, Manczak M,
Calkins MJ, Truong Q, Reddy TP, Reddy AP, Shirendeb U, Lo HH, Rabinovitch PS,
Reddy PH. Mitochondria-targeted catalase reduces abnormal APP processing,
amyloid beta production, and BACE1 in a mouse model of Alzheimer's disease:
Implications for neuroprotection and lifespan extension. Hum Mol Genet. 21(13):2973-90,
2012.
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Cheung WW and Mao
P. Recent Advances in Obesity: Genetics and Beyond. ISRN
Endocrinology, 2012 (open access)
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Mao P, Meshul C,
Thuillier and Reddy PH. CART is a potential endogenous antioxidant peptide
and localized in mitochondria, PLoS One 2012;7(1):e29343 (open
access).
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Mao P, Gallagher
P, Nedungadi S, Manczak M, Shirendeb U, Kohama S, Ferguson B, Park BS,
Reddy PH. Mitochondrial DNA deletions and differential mitochondrial DNA
content in Rhesus monkeys: implications for aging. Biochim Biophys
Acta- Molecular Basis of Disease 1822(2):111-119, 2011.
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Shirendeb U,
Calkins M, Manczak M, Anekonda V, Dufour B, McBride J, Mao P, Reddy
PH. Mutant huntingtin’s interaction with mitochondrial protein Drp1 impairs
mitochondrial biogenesis and causes defective axonal transport and synaptic
degeneration in Huntington’s disease. Hum Mol Genet. 20(7):1438-55,
2011.
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Calkins M,
Manczak M, Mao P, Shirendeb U. Impaired mitochondrial biogenesis, defective
axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic
degeneration in a mouse model of Alzheimer’s disease. Hum Mol Genet.
20(23):4515-29, 2011.
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Mao P and Reddy
PH. Aging and amyloid beta-induced oxidative DNA damage and mitochondrial
dysfunction in Alzheimer's disease: Implications for early intervention and
therapeutics. Biochim Biophys Acta. Molecular mechanisms of
disease, 1812(11):1359-1370, 2011 (this review was listed as one of the
most read articles in the journal, 2011; From that time and present, it is one
of Elsevier Editor’s choice of authors’ research).
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Ricoy UM, Mao P,
Manczak M, Reddy PH and Frerking ME. A transgenic mouse model for Alzheimer’s
disease has impaired synaptic gain but normal synaptic dynamics Neuroscience
Letter 500(3):212-5, 2011.
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Mao P. Potential
antidepressant role of neurotransmitter CART: implications for mental
disorders. Depression Research and Treatment, 2011:762139, 2011.
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Reddy PH, Reddy
TP, Manczak M, Calkins MJ, Shirendeb U, Mao P. Dynamin -Related
Protein 1 and Mitochondrial Fragmentation in Neurodegenerative Diseases. Brain
Research Reviews, 67(1-2):103-18, 2011.
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Shirendeb U,
Reddy AP, Manczak M, Calkins MJ, Mao P, Tagle DA, Reddy PH.
Abnormal mitochondrial dynamics and mutant huntingtin oligomers in
Huntington’s disease: Implications for selective neuronal damage. Hum
Mol Genet. 20(7):1438-55, 2011.
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Reddy TP, Manczak
M, Calkins MJ, Mao P, Reddy AP, Shirendeb U, Park B, and Reddy PH. Toxicity of neurons treated with
herbicides and neuroprotection by mitochondria-targeted antioxidant SS31. Int.
J. Environ. Res. Public Health 8: 203-221, 2011.
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Manczak M, Mao P,
Calkins MJ, Cornea A, Reddy AP, Murphy MP, Szeto HH, Park B, and
Reddy PH. Mitochondria-Targeted Antioxidants Protect Against Amyloid-β Toxicity
in Alzheimer’s Disease Neurons. J Alzheimers Dis 20 Suppl
2:S609-31, 2010.
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Reddy PH, Manczak
M, Mao P, Calkins MJ, Reddy AP, Shirendeb U. Amyloid-beta and
Mitochondria in Aging and Alzheimer's Disease: Implications for Synaptic Damage
and Cognitive Decline. J Alzheimers Dis. 20 Suppl
2:S499-512,2010.
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Mao P and Reddy
PH. Is Multiple Sclerosis a Mitochondrial Disease? Biochim Biophys
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Acta. Molecular mechanisms of disease,
1802(1):66-79, 2010.
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Reddy PH, Manczak
M, Nakamura K, Zhao W, Bebbington C, Yarranton G and Mao P. Immunization of the
granulocyte macrophage colony-stimulating factor suppresses microglia activity:
Implications for anti-inflammatory effects in Alzheimer’s disease and multiple
sclerosis. The Journal of Neurochemistry. 111(6):1514-28, 2009.
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Manczak M, Mao P,
Nakamura K, Bebbington C, Park B, Reddy PH. Neutralization of Granulocyte
Macrophage Colony Stimulating Factor Decreases Amyloid Beta 1-42 and Suppresses
Microglial Activity in a Transgenic Mouse Model of Alzheimer's Disease. Hum
Mol Genet. 18(20):3876-93, 2009.
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Reddy PH, Mao P
and Manczak M. Mitchondrial Structural and Functional Dynamics in
Huntington’s disease. Brain Res Rev. 61(1):33-48, 2009.
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Mao P, Tao YX,
Fukoyama M, Tao F, Li D, Watanabe M and Johns RA. Cloning and
characterization of E-dlg, a novel splice variant of mouse homologue of the Drosophila discs
large tumor suppressor binds preferentially to SAP102. The IUBMB Life (the
International Union of Biochemistry and Molecular Biology Life), 60(10):684-92,
2008. (GenBank accession # for E-dlg: AY159380)
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Mao P, Ardeshiri
A, Jacks R, Yang S, Hurn P and Alkayed N. Mitochondrial mechanism of
neuroprotection by CART. Eur J Neurosci. 26(3): 624-32, 2007.
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Koerner IP, Jacks
R, DeBarber AE, Koop D, Mao P, Grant DF, Alkayed NJ. Polymorphisms in the human
soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic
injury. J Neurosci.27:4642-9, 2007.
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Mao P, Jacks R.
Transcriptional activity by cocaine-amphetamine regulated transcript (CART). Molecular
Psychiatry, 12(3): 223-4. 2007.
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Fang M, Tao YX,
He F, Zhang M, Levine C, Mao P, Tao F, Chou C, Sadegh-Nasseri S, and Johns
RA. Synaptic PDZ domain-mediated protein interactions are disrupted by
inhalathonal anesthetics. J Biol Chem. 278(38): 36669-75,
2003.
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Tao F, Tao YX,
Mao P, Zhao C, Li D, Liaw WJ, Raja SN, and Johns RA. Intact carrageenan-induced
thermal hyperalgesia in mice lacking inducible nitric oxide synthase. Neuroscience 120(3):
847-854, 2003.
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Tao F, Tao YX,
Mao P and Johns RA. Role of PSD-95 in the maintenance of peripheral nerve
injury-induced neuropathic pain in rats. Neuroscience 117(3):
731-739, 2003.
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Takimoto M, Wei
G, Dosaka-Akita H, Mao P, Kondo S, Sakuragi N, Chiba I, Miura T, Itoh N, Sasao
T, Koya RC, Tsukamoto T, Fujimoto S, Katoh H, Kuzumaki N. Frequent expression
of new cancer/testis gene D40/AF15q14 in lung cancers of smokers. Br J
Cancer 86(11): 1757-62, 2002.
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Tao F, Tao YX,
Gonzalez JA, Fang M, Mao P, Johns RA. Knockdown of PSD-95/SAP90 delays the
development of neuropathic pain in rats. Neuroreport. 12(15):
3251-5, 2001.
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Mao P, Takimoto
M, Wei G, Yamazaki H, Miura T, Johnson AC, Kuzumaki N. Molecular analysis of
the GCF gene identifies revisions to the cDNA and amino acid sequences.
Biochimica et Biophysica Acta –Gene Structure and Expression.
1447:125-131, 1999.
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Mao P. Revisions
of the cDNA and primary protein structure of human transcription factor GCF. The
Hokkaido Journal of Medical Science 74(4): 315-330, 1999.
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Takimoto M, Wei
G, Mao P, Koya CR, Miura T and Kuzumaki N. Isolation of cDNAs that cover
the entire coding region of a novel human protein D40. Nucleic Acids
Symposium Series No: 42, 69-70 Oxford University Press, 1999.9.
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Wei G, Takimoto
M, Yoshida I, Mao P, Koya RC, Miura T, Kuzumaki N. Chromosomal assignment of a
novel human gene D40 (for the first time, D40 gene mapped to the long arm of
chromosome 15q14-15). Wei G, Takimoto M, Yoshida I, Mao PZ, Koya RC, Miura T,
Kuzumaki N. Nucleic Acids Symp Series No: 42, 71-2, 1999.
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Mao P, Takimoto
M, Yamazaki H, Wei G, Miura T, Alfred CJ and Kuzumaki N.
Revision of cDNA and protein structure of transcription factor GCF. Nucleic
Acids Symposium Series No: 39,199-200 Oxford University Press. 1998.9.
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Takimoto M, Wei
G, Mao P, Koya CR, Miura T and Kuzumaki N. Molecular cloning of a novel human
protein that binds specifically to nuclear factor GCF. Nucleic Acids
Symposium Series No: 39, 201-202 Oxford University Press. 1998.9.
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Mao P, Takimoto
M, Wei G, Sakai N, Senmaru N, Fujita H, Kuzumaki N. Expression of the GCF
protein is dependent on the cell cycle. Nucleic Acids Symposium Series No.
37, 119-120 Oxford University Press. 1997.11.
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Takimoto M, Mao
P, Wei G, Senmaru N and Kuzumaki N. Lack of homodimerization through the
leucine zipper-like region of a mammalian transcriptional repressor GCF in
yeast cells. Nucleic Acids Symposium Series No. 35, 229-230
Oxford University Press. 1996.9.
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Mao P, Li A and
Hu Z. Labeling of rat LH and prolactin with iodine-125. Chemical
Abstracts, Vol. 118, No. 6, Biochem Methods 407, 1993.3.
(Date of patent obtained: 12/13/1996 from The Bureau of the patent of China).
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Hu Z, Fang X, Mao
P, Gu F, Li Y, Zhang T, Xiao S, et al. Suppression of serum gonadotropin
and gonadal hormones in adult male and female rhesus monkeys by potent LHRH
antagonists TX51 and TX46-2. Contraception 46(2): 147, 1992.
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Fang X, Sun Z,
Mao P, Xiao S. Evaluation of biological activity of LHRH antagonists by three
methods. Contraception, 46(2): 135-137, 1992.
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Mao P, Zhou C, Lu
Q and She Y. Effects of traditional Chinese medicines Huang Qin and Dong
Gui-San on the functions of corpora lutea in the psudopregnant rats. Journal
of the Integration of Chinese Medicine and Western Medicine, Special Issue of
Basic Research: 159-162, 1990.