Jithesh Kottur

Icahn School of Medicine at Mount Sinai, New York, USA

Email: jithesh.kottur@mssm.edu , kotturjithesh@gmail.com

Research fields

Structural Biology

Drug discovery

DNA polymerase

Targeted protein degradation

Qualifications

2017 Ph.D., Regional Centre for Biotechnology, India

2011 M.Sc., Kannur University, India

Publications (Selected)

1. Yu,X., Li,D., Kottur,J., Shen,Y., Kim,H.S., Park,K.-S., Tsai,Y.-H., Gong,W., Wang,J., Suzuki,K., et al. (2021) A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models. Sci Transl Med, 13, eabj1578. (Equal Contribution)
2. Johnson, M.K., Kottur, J and Nair, D.T. (2019) A polar filter in DNA polymerases prevents ribonucleotide incorporation Nucleic Acids Res. 47, 10693-10705
3. Kottur, J and Nair, D. T. (2018) Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction. Nucleic Acids Res.46, 5875-5885.
4. Kottur, J. and Nair, D.T. (2016) Reactive Oxygen Species Play an Important Role in the Bactericidal Activity of Quinolone Antibiotics. Angew Chem Int Ed Engl, 55, 2397-2400.
5. Ghodke, P.P., Gore, K.R., Harikrishna, S., Samanta, B., Kottur, J., Nair, D.T. and Pradeepkumar, P.I. (2016) The N(2)-Furfuryl-deoxyguanosine Adduct Does Not Alter the Structure of B-DNA. J Org Chem, 81, 502-511.
6. Weinert, T., Olieric, V., Waltersperger, S., Panepucci, E., Chen, L., Zhang, H., Zhou, D., Rose, J., Ebihara, A., Kuramitsu, S., Kottur, J. et al. (2015) Fast native-SAD phasing for routine macromolecular structure determination. Nature Methods, 12, 131-133.
7. Kottur, J., Sharma, A., Gore, K.R., Narayanan, N., Samanta, B., Pradeepkumar, P.I. and Nair, D.T. (2015) Unique structural features in DNA polymerase IV enable efficient bypass of the N2 adduct induced by the nitrofurazone antibiotic. Structure, 23, 56-67.
8. Nair, D.T., Kottur, J. and Sharma, R. (2015) A rescue act: Translesion DNA synthesis past N(2) -deoxyguanosine adducts. IUBMB Life, 67, 564-574.
9. Sharma, A., Kottur, J., Narayanan, N. and Nair, D.T. (2013) A strategically located serine residue is critical for the mutator activity of DNA polymerase IV from Escherichia coli. Nucleic acids research, 41, 5104-5114.
10. Khan, M. and Jithesh, K. (2012) Expression and purification of organic solvent stable lipase from soil metagenomic library. World J Microbiol Biotechnol, 28, 2417-2424.
11. Khan, M., Jithesh, K. and Mookambikay, R. (2013) Cloning and characterization of two functionally diverse lipases from soil metagenome. J Gen Appl Microbiol, 59, 21-31.