Dr. Elias J. Fernandez

University of Tennessee, USA

Associate Professor

Email: efernan1@utk.edu

Qualifications

1995  Ph.D., Loyola University Chicago, Biophysical Chemistry

1988  B.Sc./M.Sc., Bangalore University, Physics with Chemistry & Mathematics

Publications (selected)

1. Putcha, B.-D. K., Wright, E., Brunzelle, JS, and Elias J. Fernandez*. Structural basis for negative cooperativity within agonist-bound TR:RXR heterodimers. (2012) Proc Natl Acad Sci U S A., Apr 17;109(16):6084-7.
2. Wright, E., Busby, SA, Wisecarver, S., Vincent, J, Griffin, PR, and Elias J. Fernandez*. Helix 11 Dynamics is Critical for Constitutive Androstane Receptor Activity. (2011) Structure, Jan 12;19(1):37-44.
3. Putcha, B.-D. K. and Elias Fernandez*. Direct inter-domain interactions can mediate allosterism in the thyroid receptor. J. Biol. Chem. (2009) 21;284(34):22517-24.
4. Wright Edward, Vincent J, Fernandez EJ*. Thermodynamic Characterization of the Interaction Between CAR/RXR and SRC-1 Peptide by Isothermal Titration Calorimetry. Biochemistry (2007) 46(3):862-70.*Listed in Faculty of 1000 Biology [16-Jan-2007] to [15-Feb-2007]
5. Shan L, Vincent J, Brunzelle JS, Dussault I, Lin M, Ianculescu I, Sherman MA, Forman BM, Fernandez EJ*. Structure of the murine constitutive androstane receptor complexed to androstenol; a molecular basis for inverse agonism. Molecular Cell. (2004) Dec 22; 16(6):907-17.**Previewed in Cell Metabolism (2005) 1(1):6-8, Inaugural Issue
6. Vincent, J. Shan, L. Fan, M. Brunzelle, J. S. Forman, B. M. Fernandez, E*. Crystallographic analysis of murine constitutive androstane receptor ligand-binding domain complexed with 5alpha-androst-16-en-3alpha-ol. Acta Cryst. (2005) F61:156-159.
7. Fernandez, Elias J.* & Lolis, Elias.* (2002) “Structure, Function, and Inhibition of Chemokines” Annu. Rev. Pharmacol. Toxicol. 42: 469-99.
8. Shao, W., Fernandez, E., Wilken, J., Thompson, D.A., Schweitzer, B.I. & Lolis, E. (2001) “CCR2 and CCR5 receptor-binding properties of herpesvirus-8 vMIP-II based on sequence analysis and its solution structure.” Eur. J. Biochem. 268(10):2948-59.
9. Fernandez, E.J., Wilken, J., Thompson, D., Peiper, S., & Lolis, E. (2000) “Comparison of the Structure of vMIP-II with Eotaxin-1, RANTES, and MCP-3 Suggests a Unique Mechanism for CCR3 Activation” Biochemistry, 39, 12837-12844.
10. Fernandez, E.J., Abad-Zapatero, C., & bOlsen, K.W. (2000) “Crystal structure of Lys182 – bLys282 Crosslinked Hemoglobin: A possible Allosteric Intermediate.” J. Mol. Biol. 296(5): 1263-1274.
11. Fernandez, E., Johemiack, A. & Lolis, E. (2000) “A cryo-cooling technique for proteins grown from volatile solvents.” J. App. Cryst. 33, 168-171.
12. Dealwis, C., *Fernandez, E. J., Thompson, D.A., Simon, R.J., Siani, M.A., & Lolis, E. (1998) “Crystal structure of chemically synthesized [N33A] stromal , a potent ligand for the HIV-1 ‘fusin’ coreceptor.”acell-derived factor-1 Proc. Natl. Acad. Sci. USA 95:6941-6946.* Joint first authors.
13. Shao, W., Fernandez, E., Wilken, J., Thompson, D.A., Siani, M.A., West, J., Lolis, E., & Schweitzer, B.I. (1998) “Accessibility of selenomethionine proteins by total chemical synthesis: structural studies of human herpesvirus-8 MIP-II.” FEBS Letters 441:77-82.
14. Fernandez, E.J., Zhao L., Brunzelle, J., Olsen, K.W. (1995) “Crystallographic Studies on Cross-linked Hemoglobins” Abstr. Pap. Am. Chem. Soc. (Phys Part 2) 210: 203.
15. Saadeh, H., Thompson, C.M., Fernandez, E., Pavkovic, S.F., (1995) “1-benzyl-5-methoxycarbonylmethylthio-4-nitroimidazole.” Acta Crystallogr. C51,950-952.
16. Berkmann, C. E., Fernandez, E. J., Thompson, C. M., and Pavkovic, S. F., (1993) “Structure of 19-methylstrychninium (S)-(S)-[(R)-1,2-di(thyoxycarbonyl)ethyl] o-methyl phosphorotihioate.” Acta Crystallogr. C49, 554-556.
17. Choubal, M. D., Fernandez, E. J., Crumrine, D. C., and Pavkovic, S. F. (1992) “Structure of Diethyl cis,cis-3-8-cyclodecadiene-trans-1, 6-dicarboxylate.” Acta Crystallogr. 1501-1502.

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