TITLE:
Neutrophilia-Inducing Deferoxamine in Mice Infected with Staphylococcus aureus
AUTHORS:
Mohemid M. Al-Jebouri, Nihad A. Jafar
KEYWORDS:
Neutrophilia; Deferoxamine; Gentamicin; S. aureus; Pathology
JOURNAL NAME:
Open Journal of Pathology,
Vol.3 No.2,
April
26,
2013
ABSTRACT:
The ability to sequester iron is a primary defense mechanism against
bacterial infection. Iron chelation therapy has been considered as a possible
treatment for various infectious diseases. S.
aureus isolated from neonatal septicemia were used to study the effect of
deferoxamine and sub-minimal inhibitory concentration of gentamicine on some
virulence factors of this isolates. Also an experimental sepsis was inducted in mice and treated with gentamicin and
deferoxamine. The expression of virulence factor (alpha-hemolysin,
beta-hemolysin, delta-hemolysin, coagulase, and DNase) by Staphylococcusaureus isolates was significantly decreased (p S. aureus. In a murine model of S. aureus sepsis, deferoxamine treatment had an additional effect on survival and
bacterial eradication from the organs of septicemic mice. In vitro exposure of S. aureus isolated to gentamicin and deferoxamine led to a
decrease in the production of some virulence factors by these isolates.