S. Hirota, K. Isozaki, Y. Moriyama, K. Hashimoto, T. Nishida, S. Ishiguro, K. Kawano, M. Hanada, A. Kurata, M. Takeda, G. M. Tunio, Y. Matsuzawa, Y. Kanakura, Y. Shinomura and Y. Kitamura, “Gain-of-Function Mutations of c-kit in Human Gastrointestinal Stromal Tumors,” Science, Vol. 279, No. 5350, 1998, pp. 577-580. doi:10.1126/science.279.5350.577

has been cited by the following article:

• TITLE: Dedifferentiated Chondrosarcoma with a High-Grade Mesenchymal Component Mimicking a Gastrointestinal Stromal Tumor

  AUTHORS: Toshihiro Akisue, Kenta Kishimoto, Teruya Kawamoto, Hitomi Hara, Masahiro Kurosaka

  KEYWORDS: Dedifferentiated Chondrosarcoma; Gastrointestinal Stromal Tumor; c-kit; Histology; Immunohistochemistry

  JOURNAL NAME: Open Journal of Pathology, Vol.2 No.3, July 18, 2012

  ABSTRACT: This report presents a dedifferentiated chondrosarcoma with a unique pathologic feature. A 63-year-old man was referred with pain and a soft tissue mass in the left groin. A plain radiograph showed a mineralization in the proximal femur with partially osteolytic foci and an abnormal shadow in the soft tissue. Magnetic resonance imaging scans showed an inhomogeneous lesion with intermediate to partially low signal intensity on T1-weighted image and intermediate to high signal intensity on T2-weighted image. Microscopically, the tumor in the femur is a low-grade chondrosarcoma and the component of soft tissue was a high-grade sarcomatous lesion with an epithelial arrangement of tumor cells. A diffuse immunoreactivity to both vimentin and c-kit (CD117) antibodies was detected in the high-grade component. A dedifferentiated component is similar to those of gastrointestinal stromal tumor (GIST). This is the first case of dedifferentiated chondrosarcoma with a high-grade component mimicking a GIST.