TITLE:
Perinatal Morbidity, Mortality, and Neurodevelopmental Outcomes of Neonates with Fetal Growth Restriction
AUTHORS:
Natsuki Tamashiro, Shuko Chinen, Yoshino Kinjyo, Yukiko Chinen, Tadatsugu Kinjo, Keiko Mekaru
KEYWORDS:
Fetal Death, Fetal Growth Retardation, Neurodevelopmental Disorders, Perinatal Mortality, Umbilical Artery Doppler Velocimetry
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.14 No.3,
March
8,
2024
ABSTRACT: Objective: This study aimed to assess perinatal morbidity, mortality rates, and
neurodevelopmental outcomes in the management of fetal growth restriction (FGR)
at a single tertiary institute. Methods: Among 2465 deliveries between
2013 and 2019, 109 cases of FGR were reviewed retrospectively for causes,
indications for pregnancy termination, perinatal death, overall neonatal
outcomes, and long-term prognosis. Results: Excluding FGR due to
congenital anomalies (n = 17), the mortality rate was 3.3% (3/92). One neonate
delivered at 23 weeks developed cerebral palsy (1.1%). Retinopathy of
prematurity occurred in four neonates (4.3%). Neurodevelopmental disorders were
present in six neonates (6.5%), all of whom were delivered at 32 - 38 weeks. Significantly
lower gestational age at delivery, lower birth weight, and higher umbilical
artery resistance indices were observed in neonates with neurodevelopmental
disorders. Conclusions: Intact survival before 27 weeks of gestation at delivery with FGR is
uncommon. Neurodevelopmental
disorders may still develop after delivery at 32 - 38 weeks;
consideration should be given to the timing of delivery usingfetal ductus
venosus Doppler waveforms measurements to reduce neurodevelopmental disorders.