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https://doi.org/10.1016/S0021-9258(17)34080-2

has been cited by the following article:

• TITLE: Triphenylmethanol Conjugates of Triptorelin as Cell-Penetrating Anti-Cancer Prodrugs

  AUTHORS: Jawzah Alnakhli, Samiyah Alhamed, William Boadi, Ryan Beni

  KEYWORDS: Prodrugs, Triptorelin, Polyphenols, Prostate Cancer, Triphenylmethanol

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.11 No.11, November 20, 2023

  ABSTRACT: Some Triptorelin® (TRP) conjugates of triphenylmethanol derivatives (TPMs) with optimized hydrophobicity were synthesized by reacting 2-substituted methoxy benzenes with 1,3,5-trioxane, followed by the conjugation with TRP and sebacic acid to produce TRP-TPMs derivatives. Comparative antiproliferative assays between TRP-TPMs conjugates and the corresponding non-covalent physical mixtures of the TPMs derivatives and TRP were used to treat human acute lymphoblastic leukemia (CCRF-CEM), human ovarian adenocarcinoma (SK-OV-3) and mouse preadipocytes (3T3-L1) cells. TRP-TPMs conjugates at the 50 μM inhibited cell proliferation in CCRF-CEM, SK-OV-3 and 3T3-L1 cells by 21% - 37%, 24% - 73%, 37% - 56%, respectively following incubation for 72 h. These findings indicate that TRP-TPMs derivatives have the potential to enhance the biological activity of TRP.