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https://doi.org/10.1016/S0304-3959(02)00288-9

has been cited by the following article:

• TITLE: Newborn with Giant Non-Involuting Congenital Hemangioma: Mechanisms of Allodynia, Hyperalgesia and Treatment

  AUTHORS: Valeria Bachiocco, Ilenia Casini, Andrea Gentili

  KEYWORDS: Pain Mechanisms, Allodynia, Hyperalgesia, Newborn, Treatment

  JOURNAL NAME: Case Reports in Clinical Medicine, Vol.12 No.10, October 16, 2023

  ABSTRACT: In a newborn affected by a non involuting congenital hemangioma we measured allodynia through the application of a standard tactile stimulus and hyperalgesia through the regular administration of the Comfort scale which rates pain intensity. The baby presented signs of these pathological events over long periods of the disease. They may be attributed to the high amount of the nociceptive ligands in the hemangioma microenviroment and to the elevated concentration of TNF-alpha and IL-6 in the blood. For a long time, the pain was relieved by a combination of opioids, adjuvants and paracetamol, but also by thalidomide and unexpectedly by interferon alpha. A mechanism-based pain treatment needs to take into account the processes underlying pain and also the ongoing pathology.