TITLE:
Early Morbidity and Mortality in Neonates of Mothers with Sickle Cell Disease at the Borgou/Alibori Center Departmental Teaching Hospital in Benin
AUTHORS:
Alphonse Noudamadjo, Falilatou Agbeille Mohamed, Médétinmè Kpanidja Gérard, Mahublo Voduhe, Justin Chogou, Guedenon Romulus, Julien Didier Adedemy, Joseph Agossou
KEYWORDS:
Early, Morbidity, Mortality, Neonates, Mothers, Sickle Cell Disease, Benin
JOURNAL NAME:
Open Journal of Pediatrics,
Vol.13 No.3,
May
30,
2023
ABSTRACT: Introduction: Association of sickle cell disease and pregnancy is a risky situation
for both the mother and neonate. Objective: To determine the early
morbidity and mortality among neonates of mothers with sickle cell disease at
Borgou/Alibori Center Departmental Teaching Hospital (CHUD B/A) in Benin. Patients
and Methods: This was a descriptive and analytical observational study
conducted at CHUD-B/A from January 1, 2015, to August 31, 2019. It included
pregnant women with sickle cell disease who gave birth to a liveborn neonate at
the term of at least 28 weeks of amenorrhea. Variables studied were sociodemographic, clinical, and evolutionary. Analysis of
the factors associated with early death was also carried out with a
significance threshold set at p Results: Out of a
total of 119 pregnant women, 95 neonates were recorded. Main morbidities were:
prematurity and intrauterine growth
restriction (49.5%); respiratory distress (40%), bacterial infection
(30.5%), and perinatal asphyxia (21.1%). Early mortality rate was 8.4%. In
bivariate analysis, the factors associated with early death were: parity (p
g (p Conclusion: One out of two neonates of
mothers with sickle cell disease has a low birth weight. Early mortality is
high due to perinatal asphyxia. Hence the multidisciplinary care of these
mothers.