TITLE:
Effects of Aspirin on Pregnancy Outcome and Serum Endothelin-1 and Thrombomodulin Levels in Pregnancy Patients with Chronic Hypertension
AUTHORS:
Yu Cai, Jianjun Zhai, Bibo Feng, Rui Chen, Xingyue Tian
KEYWORDS:
Pregnancy with Chronic Hypertension, Aspirin, Maternal and Fetal Outcomes, ET-1, TM
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.11 No.8,
August
27,
2021
ABSTRACT: Objective: To investigate the effect of aspirin on pregnancy outcome and serum
levels of endothelin-1 (ET-1) and thrombomodulin (TM) in pregnancy patients
with chronic hypertension. Methods: Selected patients with chronic
hypertension (mild to moderate) during pregnancy, who were enrolled and
delivered in the Beijing Tongren Hospital Department of Obstetrics and Gynecology
between January 1, 2019 and December 30, 2020. The patients were randomly
divided into control group (60) and experimental group (60). The control group
was treated with labetalol and the test group was treated with labetalol and
aspirin. The therapeutic effect and pregnancy outcome of the two groups were
compared. The serum levels of ET-1 and TM were measured before treatment and
one week after treatment. Results: Systolic blood pressure (SBP)
decreased significantly one week after treatment in the two groups (P Conclusion: Besides routine treatment, aspirin can improve the
outcome of pregnant women with chronic hypertension, which may be related to
the regulation of ET-1 and TM by aspirin.