TITLE:
Autologous Adipose-Derived Mesenchymal Stem Cells Embedded in Platelet-Rich Fibrin in Diabetic Foot Ulcers
AUTHORS:
Charbel Khalil, Diana Chaker, Rawad Salameh, Yvonne-Elise Germanos, Elie El Kayem, Fady Nader, Jessica Habbouche, Rodrigue Chemaly, Albert Azar, Ahmad Ibrahim
KEYWORDS:
Diabetic Foot Ulcer, Diabetes, Mesenchymal Stem Cells, Adipose Tissue, Platelet Rich Fibrin
JOURNAL NAME:
Open Journal of Regenerative Medicine,
Vol.10 No.2,
June
30,
2021
ABSTRACT: Context and Aim: Mesenchymal stem cells (MSCs) and platelet-rich fibrin (PRF) have emerged as ideal candidates for advanced therapies of various therapeutically-challenging diseases; however, their regenerative potential in diabetic foot ulcers (DFU) has not been well determined. In this study, we reviewed our clinical experience in mitigating chronic ulcer complications of diabetic foot through a conventional treatment of autologous adipose-derived MSCs embedded in PRF with pure PRF injections. Materials and Methods: The present study was carried out in 10 patients with an open DFU wound selected over a period of 1 year starting from April 2019. Patients were either injected with PRF alone (Group A) or injected with MSCs derived from adipose tissue (ADMSC) embedded in (PRF (Group B). Results: Patients in Group B had a better healing index when compared to Group A. Conclusion: Use of ADMSC embedded in PRF showed promising results to treat DFU.