TITLE:
Synthesis Characterization and Biological Activities of an Enamine Derivative and Its Coordination Compounds
AUTHORS:
Temitayo Aiyelabola, Johannes Jordaan, Daniel Otto, Ezekiel Akinkunmi
KEYWORDS:
Enamine, Nuclear Magnetic Resonance, Antimicrobial Activity, Cytotoxicity, EDX, Therapeutic Coordination Compound, Brine Shrimp Lethality Bioassay
JOURNAL NAME:
Advances in Biological Chemistry,
Vol.10 No.6,
December
22,
2020
ABSTRACT: The medicinal uses and applications of metal complexes
are of increasing clinical and commercial importance; this is as a result of some
level of success achieved so far. In this regard,
novel enamine free-base ligands were synthesized by the condensation of terephthalaldehyde
and 2-(methylamino)ethanol. This afforded a dinegative ONNO donor enamine, free base, characterized using 1H and 13C NMR, Fourier-transformed infrared and UV-vis spectroscopy. Coordination
compounds of the enamine were also synthesized using Cu(II), Ni(II), Co(II) and
VO(IV) ions. These complexes were characterized by electronic, IR spectrophotometry,
mass spectrometry, magnetic susceptibility and EDX. The compounds were thereafter evaluated for their antimicrobial
and cytotoxic activities. The data obtained were supportive of an octahedral geometry for the Cu(II) complex, a square-pyramidal geometry
for the vanadium complex and a 4-coordinate square-planar geometry for both the
cobalt and nickel complexes. The magnetic susceptibility data revealed that the
complexes are magnetically dilute and mononuclear with exception of the cobalt complex.
The ligands and the complexes did not exhibit significant antimicrobial and cytotoxic
assays, indicative of the nontoxicity of the ligand and complexes.