TITLE:
Dysfunction of Fronto-Subcortical Circuitry in Fronto-Temporal Dementia
AUTHORS:
S. Laurentino, E. B. Sougey
KEYWORDS:
Frontotemporal Dementia, Fronto-Subcortical Circuitry, Basal Ganglia, Neurotransmitters, Fronto-Subcortical Syndrome
JOURNAL NAME:
Open Journal of Psychiatry,
Vol.10 No.4,
August
27,
2020
ABSTRACT: In the last years, some studies have shown that behavior disorder seems in frontotemporal dementia is related to dysfunction in the fronto-subcortical circuitry. Objectives: We did a narrative literature review concerning fronto-subcortical circuitry and frontotemporal dementia (FTD). Methods: Manuscripts related to fronto-subcortical network and frontotemporal dementia were selected for further analysis. Results: From the executions of simple motor actions to the most complex behaviors like goal-direct behavior and social cognition, the fronto-subcortical circuitry involves an intrigued network of fibers that reaches to basal ganglia nuclei. Recently, researchers have shown five parallel fronto-subcortical circuits integrating and segregating information from the frontal cortex to basal ganglia. Understanding the relationship between the fronto-subcortical circuit dysfunctions and neurodegenerative diseases requires studying the functional anatomy and neurochemical basis involved. Conclusions: In this view, it is essential to review the functional anatomy of the fronto-subcortical network, and it’s correlated with clinical aspects to pursuing a better therapeutic approach.