TITLE:
Syntheses of Coordination Compounds of (±)-2-Amino-3-(4-Hydroxyphenyl)Propionic Acid, Mixed Ligand Complexes and Their Biological Activities
AUTHORS:
Temitayo O. Aiyelabola, Ezekiel O. Akinkunmi, Raphael Akinade
KEYWORDS:
Coordination Compounds, Antimicrobial Agent, Antioxidant, Mixed Lig-and, 1, 10-Phenantroline
JOURNAL NAME:
Advances in Biological Chemistry,
Vol.10 No.2,
March
19,
2020
ABSTRACT: Coordination compounds of
(±)-2-amino-3-(4-hydroxyphenyl) propionic acid and
their mixed ligand complexes with 1,10-phenantroline were synthesized, characterized using electronic and
infrared spectral analyses and magnetic susceptibility. The compounds were
evaluated for antimicrobial and antioxidant activities. Four different assays
were applied for evaluating antioxidant capacity of the compounds. The results
obtained indicated a diametric square planar geometry for both cobalt (±)-2-amino-3-(4-hydroxyphenyl) propionic
acid complex and its mixed ligand
complex. It was suggested that for the binary cobalt(II) complex, the phenolic
substituent coordinated with neighbouring
central metal ions. However, for the ternary cobalt(II) complex it was suggested it was deprotonated. Octahedral geometry was
proposed for both copper complexes. Square planar geometry was indicated for the nickel(±)-2-amino-3-(4-hydroxyphenyl) propionic acid complex and a mixture of
square planar and octahedral geometry for the nickel mixed ligand complex. The
cobalt mixed ligand complex elicited the highest activity for all the
antioxidant assays. In most cases the binary complexes exhibited better antimicrobial activities relative
to their ternary counterparts.