Article citationsMore>>
Cui, Y., Niziolek, P.J., MacDonald, B.T., Zylstra, C.R., Alenina, N., Robinson, D.R., Zhong, Z., Matthes, S., Jacobsen, C.M., Conlon, R.A., Brommage, R., Liu, Q., Mseeh, F., Powell, D.R., Yang, Q.M., Zambrowicz, B., Gerrits, H., Gossen, J.A., He, X., Bader, M., Williams, B.O., Warman, M.L. and Robling, A.G. (2011) Lrp5 Functions in Bone to Regulate Bone Mass. Nature Medicine, 17, 684-691.
https://doi.org/10.1038/nm.2388
has been cited by the following article:
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TITLE:
LRP5 Affects Homeostasis of the Periodontal Complex
AUTHORS:
Joo-Hyung Kim, Ye-Hyun Kim, Won Hee Lim
KEYWORDS:
LRP5, Periodontal Ligament, Homeostasis
JOURNAL NAME:
Open Journal of Stomatology,
Vol.10 No.3,
March
17,
2020
ABSTRACT: Purpose: The signals responsible for homeostasis in the periodontal complex are unclear. The purpose of this study was to evaluate the role of Low-density lipoprotein receptor-related protein 5(LRP5) in this process by removing LRP5, and observing the effects of LRP5 depletion on cells of the periodontal structures. Material and Methods: The function of this LRP5 was evaluated by conditional elimination of the LRP5 gene using an Osteocalcin Cre driver. The OCN-Cre; mice were examined using micro-CT and histology, immunohistochemistry to evaluate the periodontal complex. Results: Elimination of LRP5 in the periodontal complex of OCN-Cre;mice results in a different expression of Fibromodulin in the periodontal ligament space. A decrease in osteoclastic activity was found in the periodontal ligament. Conclusion: Osteoclastic activities are decreased and expression of fibromodulin is decreased, which implies the involvement of LRP5 in homeostasis of the periodontal ligament.
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