TITLE:
Studying the Effect of Laparoscopic Ovarian Drilling on Ovarian Reserve via Measurement of Anti-Mullerian Hormone in Polycystic Ovarian Syndrome Patients
AUTHORS:
Sherif Gaafar, Fady M. Shawky Moiety, Hadir Ward, Youssry Mohey Eldin
KEYWORDS:
Polycystic Ovarian Syndrome, AMH, LOD
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.8 No.14,
December
27,
2018
ABSTRACT: Background: Polycystic ovarian syndrome (PCOS) is the most
common cause of anovulation and it also causes other metabolic and endocrinal
disorders. Lines of management of PCOS include several medical options in addition
to laparoscopic ovarian diathermy (LOD). However, the effect of LOD on ovarian
reserve has always been a concern.
Advocates to LOD claimed that the decrease in ovarian reserve following LOD is
merit not a drawback. Study Design: A case series study aimed at
investigating the effect of LOD on Anti-Mullerian hormone (AMH) and trying to
find the relation between AMH levels and success of LOD. Patients and Methods: The study was carried out on 30 clomiphene citrate resistant PCOS patients from
EL Shatby maternity hospital. Hormonal profile including; FSH, LH, free
testosterone, AMH and progesterone was done preoperatively and 3 months after
LOD. Results: After LOD 19/30 cases (63.3%) had spontaneous ovulation.
After LOD the mean AMH decreased significantly from 9.12 ng/ml to 7.66 ng/ml (p
= 0.006*). Responders had significantly lower preoperative AMH as compared to
non-responders (8.01 ng/ml Vs 10.01 ng/ml). Responders had a highly significant
(p Conclusion: Measurement of serum AMH concentration before LOD may be a
useful tool in predicting responders to LOD and help in patient selection.