TITLE:
The Application of New Chiral Ferrocene Ligands in Asymmetric Transfer Hydrogenation of Ketones
AUTHORS:
Yuan-Zhao Mo, Quan-Jun Wang, Hui-Fang Nie, Qiao-Feng Wang
KEYWORDS:
Asymmetric Transfer Hydrogenation, Ferrocene, Ligand, Ketone
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.8 No.1,
February
23,
2018
ABSTRACT: Four
easily available ferrocenyl chiral ligands have been screened firstly for ruthenium
(II)-catalyzed asymmetric transfer hydrogenation of acetophenone with HCOOH/Et3N
azeotrope as the hydrogen source. A moderate chemical yield of 1-phenylethanol
with 83% ee was obtained when (RC, SFc)-1-(Diphe-nylphosphino)-2-[1-N-(3-methylpyridin-2-ylmethyl) ethyl]
ferrocene (L1) was used. Particularly, both ruthenium and
iridium could coordinate with L1 to accomplish the asymmetric
reduction of series of aromatic ketones separately. The desired
products were achieved with up to 86% ee.