TITLE:
Green Synthesis of Novel 5-Arylazo-2-[(2S, 3S, 4R, 5R)-3, 4, 5-Trihydroxy-6-(Hydroxymethyl) Tetrahydro-2H-Pyran-2-Yloxy]-4, 6-Dimethyl 3-Nicotinonitrile
AUTHORS:
Magda H. Abdellattif, Mohamed Mohamed Helmy Arief, Adel A. H. Abdel-Rahman, Abdel-Aleem H. Abdel Aleem, Abdel Moneam Farag Eissa
KEYWORDS:
Green Chemistry, Green Protocol, Pyridones, Fluroazo Compounds, Microwave
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.7 No.4,
December
15,
2017
ABSTRACT: Introduction: Pyridone derivatives played important roles
in the last decade to approach many and different functionalities, especially
as antitumor, antibacterial, anti-fungal, and many of pharmacological activities. Methodology: Novel compounds of 5-Arylazo-2-[(substituted)-3, 4,
5-trihydroxy-6-(hydroxymethyl) tetrahydro-2H-pyran-2-yloxy]-4, 6-dimethylnicotinonitrile, (3a-e),
generally called (fluroarylazopyridine glucosides) were synthesised via
green protocol, microwave. Results: The compounds were investigated by
(IR, 1HNMR, 13CNMR and mass spectrometry). Where some of
pharmacological activities like antibacterial and antifungal studies had been
investigated and characterized. It was found that 3a-d had characterized by
high activities as antibacterial and antifungal. Where microwave synthetic
methods were more efficient, gave higher products quantity, and more saving for
time requirement and for using of much more solvents.