TITLE:
Treatment Results of Adjuvant Chemotherapy after Radical Hysterectomy for Intermediate-Risk Stage IB-IIB Cervical Cancer
AUTHORS:
Hongwu Wen, Tongyu Liu, Zhaoyi Feng, Weiping Huang, Ke Ma, Xia Tao
KEYWORDS:
Cervical Cancer, Chemotherapy, Radiotherapy, Prognosis
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.6 No.12,
November
26,
2015
ABSTRACT: Objective: The objective is to evaluate the effectiveness of chemotherapy
as postoperative adjuvant therapy for stage IB-IIB cervical cancer with intermediate-risk
factors. Methods: We retrospectively reviewed the medical records of 119 cervical
cancer patients with intermediate-risk factors treated with radical
hysterectomy and pelvic lymphadenectomy from December 1997 to September 2010.
The intermediate-risk factors included bulky tumor (≥4 cm), lymphovascular
space invasion, and deep stromal invasion. Sixteen patients did not receive
adjuvant therapy (observation group); 73 were treated with chemotherapy (CT
group); 30 were treated with adjuvant radiation therapy (RT group). The
significance of the clinical parameters, 3- and 5-year overall survival (OS)
rates of each group, was analyzed. Results: The 3- and 5-year OS rates between
the observation group and adjuvant therapy group (CT plus RT groups) were not
statistically different (3-year OS: 100% and 94.4%, respectively; 5-year OS:
100% and 92.3%, respectively; p > 0.05). The 3- and 5-year OS rates between
the CT group and RT group were also not statistically different (3-year OS:
93.6% and 96.4%, respectively; 5-year OS: 80.7% and 96.4%, respectively; p Univariate and
multivariate analysis of survival indicated that different adjuvant therapies
were not independent prognostic indicators for IB-IIB cervical cancer patients
with intermediate-risk factors. Conclusions: CT may have equivalent therapeutic
effect as RT for stage IB-IIB cervical cancer patients with intermediate-risk
factors after radical surgery, and prospective randomized trial is needed to study
the effect of CT in these patients.