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Alinari, L., Yu, B., Christian, B.A., Yan, F., Shin, J., Lapalombella, R., Hertlein, E., Lustberg, M.E., Quinion, C., Zhang, X., Lozanski, G., Muthusamy, N., Prætorius-Ibba, M., O’Connor, O.A., Goldenberg, D.M., Byrd, J.C., Blum, K.A. and Baiocchi, R.A. (2011) Combination Anti-CD74 (Milatuzumab) and Anti-CD20 (Rituximab) Monoclonal Antibody Therapy Has in Vitro and in Vivo Activity in Mantle Cell Lymphoma. Blood, 117, 4530-4541.
http://dx.doi.org/10.1182/blood-2010-08-303354
has been cited by the following article:
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TITLE:
Simultaneous Dual Selective Targeted Delivery of Two Covalent Gemcitabine Immunochemotherapeutics and Complementary Anti-Neoplastic Potency of [Se]-Methylselenocysteine
AUTHORS:
C. P. Coyne, Toni Jones, Ryan Bear
KEYWORDS:
Gemcitabine, Anti-EGFR, Anti-HER2/neu, Covalent Immunochemotherapeutic, Gemcitabine-(C4-amide)-[Anti-EGFR], Gemcitabine-(C4-amide)-[Anti-HER2/neu], Mammary Adenocarcinoma (SKBr-3), [Se]-Methylselenocysteine
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.6 No.1,
January
16,
2015
ABSTRACT:
The anti-metabolite chemotherapeutic, gemcitabine is relatively
effective for a spectrum of neoplastic conditions that include various forms of
leukemia and adenocarcinoma/carcinoma. Rapid systemic deamination of
gemcitabine accounts for a brief plasma half-life but its sustained
administration is often curtailed by sequelae and chemotherapeutic-resistance.
A molecular strategy that diminishes these limitations is the molecular design
and synthetic production of covalent gemcitabine immunoche-motherapeutics that possess properties of selective
“targeted” delivery. The simultaneous dual selective “targeted” delivery of
gemcitabine at two separate sites on the external surface membrane of a single
cancer cell types represents a therapeutic approach that can increase cytosol
chemotherapeutic deposition; prolong chemotherapeutic plasma half-life (reduces
administration frequency); minimize innocent exposure of normal tissues and
healthy organ systems; and ultimately enhance more rapid and thorough
resolution of neoplastic cell populations. Materials and Methods: A
light-reactive gemcitabine intermediate synthesized utilizing succinimidyl
4,4-azipentanoate was covalently bound to anti-EGFR or anti-HER2/neu IgG
by exposure to UV light (354-nm) resulting in the synthesis of covalent
immunoche-motherapeutics, gemcitabine-(C4-amide)-[anti-EGFR] and gemcitabine-(C4-amide)-[anti-HER2/neu]. Cytotoxic anti-neoplastic potency of gemcitabine-(C4-amide)-[anti-EGFR] and gemcitabine-(C4-amide)-[anti-HER2/neu] betweengemcitabine-equivalent
concentrations of 10-12 M
and 10-6 M
was determined utilizing chemotherapeutic-resistant mammary adenocarcinoma
(SKRr-3). The organoselenium compound, [Se]-methylselenocysteine was evaluated
to determine if it complemented the anti-neoplastic potency of the covalent
gemcitabine immunoche-motherapeutics.
Results: Gemcitabine-(C4-amide)-[anti-EGFR],
gemcitabine-(C4-amide)-[anti-HER2/neu] and the dual simultaneous combination of gemcitabine-(C4-amide)-[anti-EGFR] with gemcitabine-(C4-amide)-[anti-HER2/neu] all had anti-neoplastic cytotoxic potency against mammary
adenocarcinoma. Gemcitabine-(C4-amide)-[anti-EGFR]
and gemcitabine-(C4-amide)-[anti-HER2/neu] produced progressive increases in anti-neoplastic
cytotoxicity that were greatest between gemcitabine-equivalent concentrations
of 10-9 M and 10-6 M.
Dual simultaneous combinations of gemcitabine-(C4-amide)-[anti-EGFR]
with gemcitabine-(C4-amide)-[anti-HER2/neu] produced levels of anti-neoplastic cytotoxicity
intermediate between each of the individual covalent gemcitabine
immunochemotherapeutics. Total anti-neoplastic cytotoxicity of the dual
simultaneous combination of gemcitabine-(C4-amide)-[anti-EGFR]
and gemcitabine-(C4-amide)-[anti-HER2/neu] against chemothe-rapeutic-resistant
mammary adenocarcinoma (SKBr-3) was substantially higher when formulated with
[Se]-methylsele-no-cysteine.
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